Manganese toxicity in critical care: Case report, literature review and recommendations for practice

Walter, E, Alsaffar, S, Livingstone, C and Ashley, SL (2015) Manganese toxicity in critical care: Case report, literature review and recommendations for practice Journal of the Intensive Care Society.

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Abstract

We present the case of a 62-year-old man on the intensive care unit with pancreatitis. Since early in his admission, and for the remainder of his prolonged stay in intensive care, he has received parenteral nutrition for intestinal failure. The whole blood manganese concentration was significantly increased after 2½ months of parenteral nutrition (PN). Three months into his stay, he developed a resting tremor and extra-pyramidal dyskinesia. In the absence of other neurological symptoms, and with no history of essential tremor, Parkinsonism or cerebral signs, hypermanganesaemia was presumed to be the cause. We review manganese metabolism and toxicity in patients who are fed with parenteral nutrition and review the current recommendations and guidelines.

Item Type:	Article
Subjects :	Biosciences and Medicine
Divisions :	Surrey research (other units)
Authors :	Walter, E, Alsaffar, S, Livingstone, C and Ashley, SL
Date :	2015
DOI :	10.1177/1751143715622216
Copyright Disclaimer :	Copyright 2015 Sage Publications
Uncontrolled Keywords :	Parenteral nutrition, critical care, manganese toxicity, monitoring
Related URLs :	Publisher
Depositing User :	Symplectic Elements
Date Deposited :	09 Aug 2016 14:19
Last Modified :	24 Jan 2020 12:59
URI:	http://epubs.surrey.ac.uk/id/eprint/811643

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