University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Linking GABA and Glutamate Levels to Cognitive Skill Acquisition During Development

Cohen Kadosh, K, Krause, B, King, AJ, Near, J and Cohen Kadosh, R (2015) Linking GABA and Glutamate Levels to Cognitive Skill Acquisition During Development Human Brain Mapping, 36. pp. 4334-4345.

[img]
Preview
Text
Linking_GABA_01.pdf - Version of Record
Available under License : See the attached licence file.

Download (429kB) | Preview
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Developmental adjustments in the balance of excitation and inhibition are thought to constrain the plasticity of sensory areas of the cortex. It is unknown however, how changes in excitatory or inhibitory neurochemical expression (glutamate, g-aminobutyric acid (GABA)) contribute to skill acquisition during development. Here we used single-voxel proton magnetic resonance spectroscopy (1 H-MRS) to reveal how differences in cortical glutamate vs. GABA ratios relate to face proficiency and working memory abilities in children and adults. We show that higher glutamate levels in the inferior frontal gyrus correlated positively with face processing proficiency in the children, but not the adults, an effect which was independent of age-dependent differences in underlying cortical gray matter. Moreover, we found that glutamate/GABA levels and gray matter volume are dissociated at the different maturational stages. These findings suggest that increased excitation during development is linked to neuroplasticity and the acquisition of new cognitive skills. They also offer a new, neurochemical approach to investigating the relationship between cognitive performance and brain development across the lifespan.

Item Type: Article
Subjects : Psychology
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
AuthorsEmailORCID
Cohen Kadosh, KUNSPECIFIEDUNSPECIFIED
Krause, BUNSPECIFIEDUNSPECIFIED
King, AJUNSPECIFIEDUNSPECIFIED
Near, JUNSPECIFIEDUNSPECIFIED
Cohen Kadosh, RUNSPECIFIEDUNSPECIFIED
Date : 9 September 2015
Identification Number : 10.1002/hbm.22921
Copyright Disclaimer : Copyright 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : magnetic resonance spectroscopy; cognitive development; c-aminobutyric acid; glutamate; cortical excitability; face processing; working memory
Depositing User : Symplectic Elements
Date Deposited : 26 Jul 2016 13:21
Last Modified : 26 Jul 2016 13:21
URI: http://epubs.surrey.ac.uk/id/eprint/811444

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800