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Rapid eye movement sleep promotes cortical plasticity in the developing brain

Dumoulin Bridi, MC, Aton, SJ, Seibt, J, Renouard, L, Coleman, T and Frank, MG (2015) Rapid eye movement sleep promotes cortical plasticity in the developing brain Science Advances, 1 (6).

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Abstract

Rapid eye movement sleep is maximal during early life, but its function in the developing brain is unknown. We investigated the role of rapid eye movement sleep in a canonical model of developmental plasticity in vivo (ocular dominance plasticity in the cat) induced by monocular deprivation. Preventing rapid eye movement sleep after monocular deprivation reduced ocular dominance plasticity and inhibited activation of a kinase critical for this plasticity (extracellular signal–regulated kinase). Chronic single-neuron recording in freely behaving cats further revealed that cortical activity during rapid eye movement sleep resembled activity present during monocular deprivation. This corresponded to times of maximal extracellular signal–regulated kinase activation. These findings indicate that rapid eye movement sleep promotes molecular and network adaptations that consolidate waking experience in the developing brain.

Item Type: Article
Subjects : Biochemical Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Dumoulin Bridi, MCUNSPECIFIEDUNSPECIFIED
Aton, SJUNSPECIFIEDUNSPECIFIED
Seibt, JUNSPECIFIEDUNSPECIFIED
Renouard, LUNSPECIFIEDUNSPECIFIED
Coleman, TUNSPECIFIEDUNSPECIFIED
Frank, MGUNSPECIFIEDUNSPECIFIED
Date : 3 July 2015
Identification Number : 10.1126/sciadv.1500105
Copyright Disclaimer : 2015 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Depositing User : Symplectic Elements
Date Deposited : 29 Jul 2016 16:26
Last Modified : 29 Jul 2016 16:26
URI: http://epubs.surrey.ac.uk/id/eprint/811317

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