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Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

Jamal-Hanjan, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, de Bruin, E, Le Quesne, J, Shafi, S, Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, SM, Lester, J, Kerr, K, Muller, S, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, NJ, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, H, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, MacKenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, K, Remmen, H, Rowan, A, Shah, R, Smith, E, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, McGranahan, N and Swanton, C (2014) Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study PLoS Biology, 12 (7). pp. 1-7.

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Abstract

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Jamal-Hanjan, MUNSPECIFIEDUNSPECIFIED
Hackshaw, AUNSPECIFIEDUNSPECIFIED
Ngai, YUNSPECIFIEDUNSPECIFIED
Shaw, JUNSPECIFIEDUNSPECIFIED
Dive, CUNSPECIFIEDUNSPECIFIED
Quezada, SUNSPECIFIEDUNSPECIFIED
Middleton, GUNSPECIFIEDUNSPECIFIED
de Bruin, EUNSPECIFIEDUNSPECIFIED
Le Quesne, JUNSPECIFIEDUNSPECIFIED
Shafi, SUNSPECIFIEDUNSPECIFIED
Falzon, MUNSPECIFIEDUNSPECIFIED
Horswell, SUNSPECIFIEDUNSPECIFIED
Blackhall, FUNSPECIFIEDUNSPECIFIED
Khan, IUNSPECIFIEDUNSPECIFIED
Janes, SUNSPECIFIEDUNSPECIFIED
Nicolson, MUNSPECIFIEDUNSPECIFIED
Lawrence, DUNSPECIFIEDUNSPECIFIED
Forster, MUNSPECIFIEDUNSPECIFIED
Fennell, DUNSPECIFIEDUNSPECIFIED
Lee, SMUNSPECIFIEDUNSPECIFIED
Lester, JUNSPECIFIEDUNSPECIFIED
Kerr, KUNSPECIFIEDUNSPECIFIED
Muller, SUNSPECIFIEDUNSPECIFIED
Iles, NUNSPECIFIEDUNSPECIFIED
Smith, SUNSPECIFIEDUNSPECIFIED
Murugaesu, NUNSPECIFIEDUNSPECIFIED
Mitter, RUNSPECIFIEDUNSPECIFIED
Salm, MUNSPECIFIEDUNSPECIFIED
Stuart, AUNSPECIFIEDUNSPECIFIED
Matthews, NUNSPECIFIEDUNSPECIFIED
Adams, HUNSPECIFIEDUNSPECIFIED
Ahmad, TUNSPECIFIEDUNSPECIFIED
Attanoos, RUNSPECIFIEDUNSPECIFIED
Bennett, JUNSPECIFIEDUNSPECIFIED
Birkbak, NJUNSPECIFIEDUNSPECIFIED
Booton, RUNSPECIFIEDUNSPECIFIED
Brady, GUNSPECIFIEDUNSPECIFIED
Buchan, KUNSPECIFIEDUNSPECIFIED
Capitano, AUNSPECIFIEDUNSPECIFIED
Chetty, MUNSPECIFIEDUNSPECIFIED
Cobbold, MUNSPECIFIEDUNSPECIFIED
Crosbie, PUNSPECIFIEDUNSPECIFIED
Davies, HUNSPECIFIEDUNSPECIFIED
Denison, AUNSPECIFIEDUNSPECIFIED
Djearman, MUNSPECIFIEDUNSPECIFIED
Goldman, JUNSPECIFIEDUNSPECIFIED
Haswell, TUNSPECIFIEDUNSPECIFIED
Joseph, LUNSPECIFIEDUNSPECIFIED
Kornaszewska, MUNSPECIFIEDUNSPECIFIED
Krebs, MUNSPECIFIEDUNSPECIFIED
Langman, GUNSPECIFIEDUNSPECIFIED
MacKenzie, MUNSPECIFIEDUNSPECIFIED
Millar, JUNSPECIFIEDUNSPECIFIED
Morgan, BUNSPECIFIEDUNSPECIFIED
Naidu, BUNSPECIFIEDUNSPECIFIED
Nonaka, DUNSPECIFIEDUNSPECIFIED
Peggs, KUNSPECIFIEDUNSPECIFIED
Pritchard, KUNSPECIFIEDUNSPECIFIED
Remmen, HUNSPECIFIEDUNSPECIFIED
Rowan, AUNSPECIFIEDUNSPECIFIED
Shah, RUNSPECIFIEDUNSPECIFIED
Smith, EUNSPECIFIEDUNSPECIFIED
Summers, YUNSPECIFIEDUNSPECIFIED
Taylor, MUNSPECIFIEDUNSPECIFIED
Veeriah, SUNSPECIFIEDUNSPECIFIED
Waller, DUNSPECIFIEDUNSPECIFIED
Wilcox, BUNSPECIFIEDUNSPECIFIED
Wilcox, MUNSPECIFIEDUNSPECIFIED
Woolhouse, IUNSPECIFIEDUNSPECIFIED
McGranahan, NUNSPECIFIEDUNSPECIFIED
Swanton, CUNSPECIFIEDUNSPECIFIED
Date : 8 July 2014
Funders : Cancer Research UK, The Rosetrees Trust, The Academy of Medical Sciences, National Institute for Health Research University College London Hospitals Biomedical Research Centre
Identification Number : 10.1371/journal.pbio.1001906
Copyright Disclaimer : Copyright 2014 Jamal-Hanjani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords : Tumor immunology
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 19 Jul 2016 10:05
Last Modified : 19 Jul 2016 10:05
URI: http://epubs.surrey.ac.uk/id/eprint/811217

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