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Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

Jamal-Hanjan, M, Hackshaw, A, Ngai, Y, Shaw, J, Dive, C, Quezada, S, Middleton, G, de Bruin, E, Le Quesne, J, Shafi, Shahida , Falzon, M, Horswell, S, Blackhall, F, Khan, I, Janes, S, Nicolson, M, Lawrence, D, Forster, M, Fennell, D, Lee, SM, Lester, J, Kerr, K, Muller, Sheila, Iles, N, Smith, S, Murugaesu, N, Mitter, R, Salm, M, Stuart, A, Matthews, N, Adams, H, Ahmad, T, Attanoos, R, Bennett, J, Birkbak, NJ, Booton, R, Brady, G, Buchan, K, Capitano, A, Chetty, M, Cobbold, M, Crosbie, P, Davies, Hilary, Denison, A, Djearman, M, Goldman, J, Haswell, T, Joseph, L, Kornaszewska, M, Krebs, M, Langman, G, MacKenzie, M, Millar, J, Morgan, B, Naidu, B, Nonaka, D, Peggs, K, Pritchard, K, Remmen, H, Rowan, A, Shah, R, Smith, Eleanor, Summers, Y, Taylor, M, Veeriah, S, Waller, D, Wilcox, B, Wilcox, M, Woolhouse, I, McGranahan, N and Swanton, C (2014) Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study PLoS Biology, 12 (7), e1001906. pp. 1-7.

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The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Jamal-Hanjan, M
Hackshaw, A
Ngai, Y
Shaw, J
Dive, C
Quezada, S
Middleton, G
de Bruin, E
Le Quesne, J
Falzon, M
Horswell, S
Blackhall, F
Khan, I
Janes, S
Nicolson, M
Lawrence, D
Forster, M
Fennell, D
Lee, SM
Lester, J
Kerr, K
Iles, N
Smith, S
Murugaesu, N
Mitter, R
Salm, M
Stuart, A
Matthews, N
Adams, H
Ahmad, T
Attanoos, R
Bennett, J
Birkbak, NJ
Booton, R
Brady, G
Buchan, K
Capitano, A
Chetty, M
Cobbold, M
Crosbie, P
Denison, A
Djearman, M
Goldman, J
Haswell, T
Joseph, L
Kornaszewska, M
Krebs, M
Langman, G
MacKenzie, M
Millar, J
Morgan, B
Naidu, B
Nonaka, D
Peggs, K
Pritchard, K
Remmen, H
Rowan, A
Shah, R
Summers, Y
Taylor, M
Veeriah, S
Waller, D
Wilcox, B
Wilcox, M
Woolhouse, I
McGranahan, N
Swanton, C
Date : 8 July 2014
Funders : Cancer Research UK, The Rosetrees Trust, The Academy of Medical Sciences, National Institute for Health Research University College London Hospitals Biomedical Research Centre
DOI : 10.1371/journal.pbio.1001906
Copyright Disclaimer : Copyright 2014 Jamal-Hanjani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords : Tumor immunology
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 19 Jul 2016 10:05
Last Modified : 16 Jan 2019 17:05

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