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In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections

Betts, JW, Sharili, AS, La Ragione, RM and Wareham, DW (2016) In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections Journal of Natural Products, 79 (6). pp. 1702-1706.

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Abstract

Bacterial infections resulting from nonsurgical traumatic wounds can be life threatening, especially those caused by multidrug-resistant (MDR) bacteria with limited therapeutic options. The antimicrobial activity of polymyxin B (1) and curcumin (2) alone and in combination was determined versus MDR bacterial isolates associated with traumatic wound infections. Cytotoxicity assays for 1 and 2 were undertaken in keratinocyte cell lines. Minimum inhibitory concentrations of 1 were significantly reduced in the presence of 2 (3- to 10-fold reduction), with synergy observed. Time− kill assays showed the combinations produced bactericidal activity. Cytotoxicity assays indicate the toxicity of 2 was reduced in the presence of 1.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Betts, JWUNSPECIFIEDUNSPECIFIED
Sharili, ASUNSPECIFIEDUNSPECIFIED
La Ragione, RMUNSPECIFIEDUNSPECIFIED
Wareham, DWUNSPECIFIEDUNSPECIFIED
Date : 13 June 2016
Identification Number : 10.1021/acs.jnatprod.6b00286
Copyright Disclaimer : This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.6b00286
Depositing User : Symplectic Elements
Date Deposited : 13 Jul 2016 08:57
Last Modified : 19 Jul 2016 10:21
URI: http://epubs.surrey.ac.uk/id/eprint/811195

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