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Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III

Ooi, EM, Chan, DC, Hodson, L, Adiels, M, Boren, J, Karpe, F, Fielding, BA, Watts, GF and Barrett, PHR (2016) Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III European Journal of Clinical Investigation, 46 (8). pp. 730-736.

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Abstract

Background Experimental data suggest that apolipoprotein (apo) C-II and C-III regulate triglyceride-rich lipoprotein (TRL) metabolism, but there are limited studies in humans. We investigated the metabolic associations of TRLs with apoC-II and apoC-III concentrations and kinetics in women. Material and methods The kinetics of plasma apoC-II, apoC-III and very low-density lipoprotein (VLDL) apoB-100 and triglycerides were measured in the postabsorptive state using stable isotopic techniques and compartmental modeling in 60 women with wide-ranging body mass index (19.5-32.9kg/m2). Results Plasma apoC-II and apoC-III concentrations were positively associated with the concentration of plasma triglycerides, VLDL1- and VLDL2- apoB-100 and triglyceride (all P<0.05). ApoC-II production rate (PR) was positively associated with VLDL1-apoB-100 concentration, VLDL1-triglyceride concentration and VLDL1-triglyceride PR, while apoC-II fractional catabolic rate (FCR) was positively associated with VLDL1-triglyceride FCR (all P<0.05). No significant associations were observed between apoC-II and VLDL2 apoB-100 or triglyceride kinetics. ApoC-III PR, but not FCR, was positively associated with VLDL1-triglyceride, and VLDL2- apoB-100 and triglyceride concentrations (all P<0.05). No significant associations were observed between apoC-III and VLDL- apoB-100 and triglyceride kinetic. In multivariable analysis, including homeostasis model assessment score, menopausal status and obesity, apoC-II concentration was significantly associated with plasma triglyceride, VLDL1 apoB-100 and -triglyceride concentrations and PR. Using the same multivariable analysis, apoC-III was significantly associated with plasma triglyceride and VLDL1- and VLDL2- apoB-100 and triglyceride concentrations and FCR. Conclusions In women, plasma apoC-II and apoC-III concentrations are regulated by their respective production rates and are significant, independent determinants of the kinetics and plasma concentrations of TRLs.

Item Type: Article
Subjects : Nutrition
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Ooi, EMUNSPECIFIEDUNSPECIFIED
Chan, DCUNSPECIFIEDUNSPECIFIED
Hodson, LUNSPECIFIEDUNSPECIFIED
Adiels, MUNSPECIFIEDUNSPECIFIED
Boren, JUNSPECIFIEDUNSPECIFIED
Karpe, FUNSPECIFIEDUNSPECIFIED
Fielding, BAUNSPECIFIEDUNSPECIFIED
Watts, GFUNSPECIFIEDUNSPECIFIED
Barrett, PHRUNSPECIFIEDUNSPECIFIED
Date : 27 July 2016
Identification Number : 10.1111/eci.12657
Copyright Disclaimer : This is the peer reviewed version of the following article: Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III, which has been published in final form at https://dx.doi.org/10.1111/eci.12657. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Depositing User : Symplectic Elements
Date Deposited : 12 Jul 2016 14:41
Last Modified : 23 Nov 2016 09:16
URI: http://epubs.surrey.ac.uk/id/eprint/811182

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