University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives

Henrotin, Y, Sanchez, C, Bay-Jensen, AC and Mobasheri, A (2016) Osteoarthritis biomarkers derived from cartilage extracellular matrix: Current status and future perspectives Annals of Physical and Rehabilitation Medicine, 59 (3). pp. 145-148.

[img]
Preview
Text
Osteoarthritis biomarkers.pdf - Version of Record
Available under License : See the attached licence file.

Download (516kB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Specific soluble biomarkers can be powerful tools for the diagnosis, prognosis and personalized management of osteoarthritis (OA). Biomarkers are potential indicators of the effect of a drug on cartilage metabolism and provide crucial information about the mechanisms of drug action. In this review, we address key questions concerning the use of biomarkers in OA management: Why do we need soluble biomarkers? What are the most widely investigated biomarkers derived from cartilage extracellular matrix? What are the most common pitfalls in interpreting soluble biomarker measurements? What are the perspectives and future research directions in this field? We review current evidence to propose that cartilage-derived soluble biomarkers are complementary “drug development tools” that can be applied during drug development from preclinical research to clinical evaluation. In the future, such biomarkers could be surrogate markers of clinical and/or imaging outcomes. Successful standardization and implementation of automated biomarker assays will facilitate their use in companion diagnostics in the context of personalized medicine for enhanced management of OA.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Henrotin, YUNSPECIFIEDUNSPECIFIED
Sanchez, CUNSPECIFIEDUNSPECIFIED
Bay-Jensen, ACUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : June 2016
Identification Number : 10.1016/j.rehab.2016.03.004
Copyright Disclaimer : © 2016 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 07 Jul 2016 10:32
Last Modified : 07 Jul 2016 10:32
URI: http://epubs.surrey.ac.uk/id/eprint/811138

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800