Ageing of the B-cell repertoire

Martin, V, Wu, Y-C, Kipling, D and Dunn-Walters, D (2015) Ageing of the B-cell repertoire Philosophical Transactions of the Royal Society B, 370 (1676).

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Abstract

Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B cells. In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.

Item Type:	Article
Subjects :	Biosciences and Medicine
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :	Name Email ORCID Martin, V Wu, Y-C Kipling, D Dunn-Walters, D
Date :	20 July 2015
DOI :	10.1098/rstb.2014.0237
Copyright Disclaimer :	© 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Depositing User :	Symplectic Elements
Date Deposited :	06 Jul 2016 14:23
Last Modified :	31 Oct 2017 18:25
URI:	http://epubs.surrey.ac.uk/id/eprint/811131

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