University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Age-related aspects of human IgM+ B cell heterogeneity

Martin, V, Wu, Y-C, Kipling, D and Dunn-Walters, D (2015) Age-related aspects of human IgM+ B cell heterogeneity Annals of the New York Academy of Sciences, 1362 (B-1 Ce). pp. 153-163.

[img]
Preview
Text
2015 Vicky Ageing and IgM 2015.pdf - Version of Record
Available under License : See the attached licence file.

Download (1MB) | Preview
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

The CD27+IgD+ B cell population, known as IgM memory, reduces with age. It is thought that this population is responsible for pneumococcal polysaccharide T-independent responses, and that the age-related reduction might be partially responsible for the increased susceptibility of older people to bacterial pathogens. There are other IgM+ B cell populations that do not express IgD. We compared the different IgM populations using high-throughput sequencing of the immunoglobulin (Ig) gene repertoire and multidimensional cell phenotyping and found that the different populations of IgM cells, defined by CD27 and IgD expression, have repertoire differences. Some of these differences are likely indicative of different selection pressures in an immune response, although the older individuals were found to have a changed repertoire in naive B cells, which may contribute to some of the changes seen in memory cells. In addition, even within the CD27+IgD+ IgM memory population there are multiple cell types. We show that the level of IgM expression varies substantially and hypothesize that this distinguishes between T-dependent and T-independent types of IgM memory cells. Significant age-related changes in the relative proportions of these populations may exacerbate the reduction in T-independent responders in old age.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Martin, VUNSPECIFIEDUNSPECIFIED
Wu, Y-CUNSPECIFIEDUNSPECIFIED
Kipling, DUNSPECIFIEDUNSPECIFIED
Dunn-Walters, DUNSPECIFIEDUNSPECIFIED
Date : 7 July 2015
Identification Number : 10.1111/nyas.12823
Copyright Disclaimer : Copyright 2015 The Authors. Annals of the New York Academy of Sciences, published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : IgM memory; immunoglobulin repertoire; aging
Depositing User : Symplectic Elements
Date Deposited : 06 Jul 2016 13:56
Last Modified : 06 Jul 2016 13:56
URI: http://epubs.surrey.ac.uk/id/eprint/811129

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800