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Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas

Michaeli, M, Tabibian-Keissar, H, Schiby, G, Shahaf, G, Pickman, Y, Hazanov, L, Rosenblatt, K, Dunn-Walters, D, Barshack, I and Mehr, R (2014) Immunoglobulin gene repertoire diversification and selection in the stomach – from gastritis to gastric lymphomas Frontiers in Immunology, 5, 264. pp. 1-14.

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Abstract

Chronic gastritis is characterized by gastric mucosal inflammation due to autoimmune responses or infection, frequently with Helicobacter pylori. Gastritis with H. pylori background can cause gastric mucosa-associated lymphoid tissue lymphoma (MALT-L), which sometimes further transforms into diffuse large B-cell lymphoma (DLBCL). However, gastric DLBCL can also be initiated de novo. The mechanisms underlying transformation into DLBCL are not completely understood.We analyzed immunoglobulin repertoires and clonal trees to investigate whether and how immunoglobulin gene repertoires, clonal diversification, and selection in gastritis, gastric MALT-L, and DLBCL differ from each other and from normal responses. The two gastritis types (positive or negative for H. pylori) had similarly diverse repertoires. MALT-L dominant clones (defined as the largest clones in each sample) presented higher diversification and longer mutational histories compared with all other conditions. DLBCL dominant clones displayed lower clonal diversification, suggesting the transforming events are triggered by similar responses in different patients. These results are surprising, as we expected to find similarities between the dominant clones of gastritis and MALT-L and between those of MALT-L and DLBCL.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Michaeli, MUNSPECIFIEDUNSPECIFIED
Tabibian-Keissar, HUNSPECIFIEDUNSPECIFIED
Schiby, GUNSPECIFIEDUNSPECIFIED
Shahaf, GUNSPECIFIEDUNSPECIFIED
Pickman, YUNSPECIFIEDUNSPECIFIED
Hazanov, LUNSPECIFIEDUNSPECIFIED
Rosenblatt, KUNSPECIFIEDUNSPECIFIED
Dunn-Walters, DUNSPECIFIEDUNSPECIFIED
Barshack, IUNSPECIFIEDUNSPECIFIED
Mehr, RUNSPECIFIEDUNSPECIFIED
Date : 3 June 2014
Identification Number : 10.3389/fimmu.2014.00264
Copyright Disclaimer : Copyright © 2014 Michaeli, Tabibian-Keissar, Schiby, Shahaf, Pickman, Hazanov, Rosenblatt , Dunn-Walters, Barshack and Mehr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Uncontrolled Keywords : B-cells, gastritis, H. pylori, MALT lymphoma, DLBCL, Ig gene, repertoire, somatic hypermutation
Depositing User : Symplectic Elements
Date Deposited : 06 Jul 2016 13:33
Last Modified : 06 Jul 2016 13:33
URI: http://epubs.surrey.ac.uk/id/eprint/811127

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