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Local Modulation of Human Brain Responses by Circadian Rhythmicity and Sleep Debt

Muto, V, Jaspar, M, Meyer, C, Kussé, C, Chellappa, SL, Degueldre, C, Balteau, E, Shaffii-Le Bourdiec, A, Luxen, A, Middleton, B, Archer, SN, Phillips, C, Collette, F, Vandewalle, G, Dijk, D and Maquet, P (2016) Local Modulation of Human Brain Responses by Circadian Rhythmicity and Sleep Debt Science, 353 (6300).

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Abstract

Human performance results from an interaction between circadian rhythmicity and homeostatic sleep pressure. Whether and how this interaction is represented at the regional brain level is not established. We quantified changes in brain responses to a sustained-attention task during 13 functional magnetic resonance imaging (fMRI) sessions scheduled across the circadian cycle during 42h of wakefulness and following recovery sleep, in 33 healthy participants. Cortical responses showed significant circadian rhythmicity, the phase of which varied across brain regions. Cortical responses also significantly decreased with accrued sleep debt. Subcortical areas exhibited primarily a circadian modulation, which closely followed the melatonin profile. These findings expand our understanding of the mechanisms involved in maintaining cognition during the day and its deterioration during sleep deprivation and circadian misalignment.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Muto, VUNSPECIFIEDUNSPECIFIED
Jaspar, MUNSPECIFIEDUNSPECIFIED
Meyer, CUNSPECIFIEDUNSPECIFIED
Kussé, CUNSPECIFIEDUNSPECIFIED
Chellappa, SLUNSPECIFIEDUNSPECIFIED
Degueldre, CUNSPECIFIEDUNSPECIFIED
Balteau, EUNSPECIFIEDUNSPECIFIED
Shaffii-Le Bourdiec, AUNSPECIFIEDUNSPECIFIED
Luxen, AUNSPECIFIEDUNSPECIFIED
Middleton, BUNSPECIFIEDUNSPECIFIED
Archer, SNUNSPECIFIEDUNSPECIFIED
Phillips, CUNSPECIFIEDUNSPECIFIED
Collette, FUNSPECIFIEDUNSPECIFIED
Vandewalle, GUNSPECIFIEDUNSPECIFIED
Dijk, DUNSPECIFIEDUNSPECIFIED
Maquet, PUNSPECIFIEDUNSPECIFIED
Date : 12 August 2016
Identification Number : 10.1126/science.aad2993
Copyright Disclaimer : This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 12 August 2016 Vol 353, DOI: 10.1126/science.aad2993
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 06 Jul 2016 11:11
Last Modified : 16 Aug 2016 07:56
URI: http://epubs.surrey.ac.uk/id/eprint/811109

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