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Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches.

Mobasheri, A, Szychlinska, MA, Leonardi, R, Al-Qahtani, M and Musumeci, G (2016) Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches. Annals of Physical and Rehabilitation Medicine, 59 (3). pp. 149-156.

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Abstract

Osteoarthritis (OA) is the most common form of joint disease. This review aimed to consolidate the current evidence that implicates the inflammatory process in the attenuation of synovial lubrication and joint tissue homeostasis in OA. Moreover, with these findings, we propose some evidence for novel therapeutic strategies for preventing and/or treating this complex disorder. The studies reviewed support that inflammatory mediators participate in the onset and progression of OA after joint injury. The flow of pro-inflammatory cytokines following an acute injury seems to be directly associated with altered lubricating ability in the joint tissue. The latter is associated with reduced level of lubricin, one of the major joint lubricants. Future research should focus on the development of new therapies that attenuate the inflammatory process and restore lubricin synthesis and function. This approach could support joint tribology and synovial lubrication leading to improved joint function and pain relief.

Item Type: Article
Subjects : School of Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Szychlinska, MAUNSPECIFIEDUNSPECIFIED
Leonardi, RUNSPECIFIEDUNSPECIFIED
Al-Qahtani, MUNSPECIFIEDUNSPECIFIED
Musumeci, GUNSPECIFIEDUNSPECIFIED
Date : 1 June 2016
Identification Number : 10.1016/j.rehab.2016.03.005
Copyright Disclaimer : © 2016 Elsevier Masson SAS. All rights reserved. This is an open-access article.
Depositing User : Symplectic Elements
Date Deposited : 27 Jun 2016 12:05
Last Modified : 27 Jun 2016 12:05
URI: http://epubs.surrey.ac.uk/id/eprint/811052

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