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The role of inflammation in the pathophysiology of DMO

Harris, F, Chalkiadakis, S and Taylor, SRJ (2016) The role of inflammation in the pathophysiology of DMO Eye News, Feb. pp. 19-23.

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Abstract

Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of these have clinically significant DMO that affects their visual acuity in at least one eye [1]. In DMO, the final common pathway is disruption of the blood-retinal barrier (BRB), resulting in leakage of fluid into the retinal layers, but causation is complicated, with many factors contributing to the process. Nevertheless, evidence is mounting that inflammation is implicated in BRB breakdown, together with hypoxia, alterations in blood flow and retinal ischaemia.

Item Type: Article
Subjects : Biosciences
Authors :
AuthorsEmailORCID
Harris, FUNSPECIFIEDUNSPECIFIED
Chalkiadakis, SUNSPECIFIEDUNSPECIFIED
Taylor, SRJUNSPECIFIEDUNSPECIFIED
Date : February 2016
Copyright Disclaimer : Copyright © Pinpoint Scotland Ltd
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 03 Jun 2016 11:17
Last Modified : 03 Jun 2016 11:17
URI: http://epubs.surrey.ac.uk/id/eprint/810913

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