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New ent-clerodane and abietane diterpenoids from the roots of Kenyan Croton megalocarpoides

Ndunda,, B, Langat, MK, Mulholland, DA, Eastman, H, Jacob, MR, Khan, SI, Walker, LA, Muhammad, I, Kerubo, LO and Midiwo, JO (2016) New ent-clerodane and abietane diterpenoids from the roots of Kenyan Croton megalocarpoides Planta Medica, 82 (11-12). pp. 1079-1086.

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Abstract

The roots of the endangered medicinal plant Croton megalocarpoides (Euphorbiaceae) collected in Kenya has been investigated. Twenty two compounds has been isolated. Among them twelve new ¬ent-clerodane (1-12) and a new abietane (13) diterpenoid alongside the known crotocorylifuran (4a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds have been evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.

Item Type: Article
Subjects : subj_Chemistry
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
AuthorsEmailORCID
Ndunda,, BUNSPECIFIEDUNSPECIFIED
Langat, MKUNSPECIFIEDUNSPECIFIED
Mulholland, DAUNSPECIFIEDUNSPECIFIED
Eastman, HUNSPECIFIEDUNSPECIFIED
Jacob, MRUNSPECIFIEDUNSPECIFIED
Khan, SIUNSPECIFIEDUNSPECIFIED
Walker, LAUNSPECIFIEDUNSPECIFIED
Muhammad, IUNSPECIFIEDUNSPECIFIED
Kerubo, LOUNSPECIFIEDUNSPECIFIED
Midiwo, JOUNSPECIFIEDUNSPECIFIED
Date : 28 June 2016
Identification Number : 10.1055/s-0042-108857
Copyright Disclaimer : Copyright 2016 Georg Thieme Verlag KG
Uncontrolled Keywords : Croton megalocarpoides, abietane, ent-clerodane, ent-trachylobane, diterpenoids, electronic circular dichroism
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2016 14:17
Last Modified : 27 Oct 2016 10:38
URI: http://epubs.surrey.ac.uk/id/eprint/810740

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