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REM sleep homeostasis in the absence of REM sleep: effects of antidepressants

Mccarthy, Andrew, Wafford, K, Shanks, E, Ligocki, M, Edgar, DM and Dijk, Derk-Jan (2016) REM sleep homeostasis in the absence of REM sleep: effects of antidepressants Neuropharmacology, 108. pp. 415-425.


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Most antidepressants suppress rapid eye movement (REM) sleep, which is thought to be important to brain function, yet the resulting REM sleep restriction is well tolerated. This study investigated the impact of antidepressants with different mechanisms of action, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCA), on the regulation of REM sleep in rats. REM sleep was first demonstrated to be homeostatically regulated using 5, 8 and 10 hours of REM-sleep specific restriction through EEG-driven triggered arousals, with an average of 91 ± 10% of lost REM sleep recovered following a 26-29 -hour recovery period. Acute treatment with the antidepressants paroxetine, citalopram and imipramine inhibited REM sleep by 84 ± 8, 84 ± 8 and 69 ± 9% respectively relative to vehicle control. The pharmacologically-induced REM sleep deficits by citalopram and paroxetine were not fully recovered, whereas, after imipramine the REM sleep deficit was fully compensated. Given the marked difference between REM sleep recovery following the administration of paroxetine, citalopram, imipramine and REM sleep restriction, the homeostatic response was further examined by pairing REM sleep specific restriction with the three antidepressants. Surprisingly, the physiologically-induced REM sleep deficits incurred prior to suppression of REM sleep by all antidepressants was consistently recovered. The data indicate that REM sleep homeostasis remains operative following subsequent treatment with antidepressants and is unaffected by additional pharmacological inhibition of REM sleep.

Item Type: Article
Subjects : subj_Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Wafford, K
Shanks, E
Ligocki, M
Edgar, DM
Date : 4 November 2016
DOI : 10.1016/j.neuropharm.2016.04.047
Copyright Disclaimer : © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (
Uncontrolled Keywords : Paradoxical sleep, recovery, selective serotonin reuptake inhibitors, tricyclic antidepressants, sleep deprivation.
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 04 May 2016 14:00
Last Modified : 17 Oct 2019 09:06

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