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Circadian regulation of human cortical excitability

Ly, JQM, Gaggioni, G, Chellappa, SL, Papachilleos, S, Brzozowski, A, Borsu, C, Rosanova, M, Sarasso, S, Middleton, B, Luxen, A, Archer, SN, Phillips, C, Dijk, D, Maquet, P, Massimini, M and Vandewalle, G (2016) Circadian regulation of human cortical excitability Nature Communications.

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Abstract

Prolonged wakefulness alters cortical excitability, which is essential for proper brain function and cognition. However, besides prior wakefulness, brain function and cognition are also affected by circadian rhythmicity. Whether the regulation of cognition involves a circadian impact on cortical excitability is unknown. Here, we assessed cortical excitability from scalp EEG-responses to transcranial magnetic stimulation in 22 participants during 29-h of wakefulness under constant conditions. Data reveal robust circadian dynamics of cortical excitability that were strongest in those individuals with highest endocrine markers of circadian amplitude. In addition, the time course of cortical excitability correlated with changes in EEG synchronization and cognitive performance. These results demonstrate that the crucial factor for cortical excitability, and basic brain function in general, is the balance between circadian rhythmicity and sleep need, rather than sleep homeostasis alone. These findings have implications for clinical applications such as noninvasive brain stimulation in neurorehabilitation.

Item Type: Article
Subjects : subj_Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Ly, JQMUNSPECIFIEDUNSPECIFIED
Gaggioni, GUNSPECIFIEDUNSPECIFIED
Chellappa, SLUNSPECIFIEDUNSPECIFIED
Papachilleos, SUNSPECIFIEDUNSPECIFIED
Brzozowski, AUNSPECIFIEDUNSPECIFIED
Borsu, CUNSPECIFIEDUNSPECIFIED
Rosanova, MUNSPECIFIEDUNSPECIFIED
Sarasso, SUNSPECIFIEDUNSPECIFIED
Middleton, BUNSPECIFIEDUNSPECIFIED
Luxen, AUNSPECIFIEDUNSPECIFIED
Archer, SNUNSPECIFIEDUNSPECIFIED
Phillips, CUNSPECIFIEDUNSPECIFIED
Dijk, DUNSPECIFIEDUNSPECIFIED
Maquet, PUNSPECIFIEDUNSPECIFIED
Massimini, MUNSPECIFIEDUNSPECIFIED
Vandewalle, GUNSPECIFIEDUNSPECIFIED
Date : 24 June 2016
Identification Number : 10.1038/ncomms11828
Copyright Disclaimer : Nature Communications is a fully open access journal. Articles are made freely accessible on publication under a CC BY license (Creative Commons Attribution 4.0 International License)
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 19 Apr 2016 16:32
Last Modified : 29 Jun 2016 11:14
URI: http://epubs.surrey.ac.uk/id/eprint/810470

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