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Modulation of total sleep time by transcranial direct current stimulation (tDCS)

Frase, L, Piosczyk, H, Zittel, S, Jahn, F, Selhausen, P, Krone, L, Feige, B, Mainberger, F, Maier, JG, Kuhn, M, Kloppel, S, Normann, C, Sterr, AM, Spiegelhalder, K, Riemann, D, Nitsche, MA and Nissen, C (2016) Modulation of total sleep time by transcranial direct current stimulation (tDCS) Neuropsychopharmacology., 41 (10). pp. 2577-2586.

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Abstract

Arousal and sleep are fundamental physiological processes, and their modulation is of high clinical significance. This study tested the hypothesis that total sleep time in humans can be modulated by the non-invasive brain stimulation technique transcranial direct current stimulation (tDCS) targeting a ‘top-down’ cortico-thalamic pathway of sleep-wake regulation. Nineteen healthy participants underwent a within-subject, repeated-measures protocol across five nights in the sleep laboratory with polysomnographic monitoring (adaptation, baseline, three experimental nights). tDCS was delivered via bi-frontal target electrodes and bi-parietal return electrodes prior to sleep (anodal ‘activation’, cathodal ‘deactivation’ and sham stimulation). Bi-frontal anodal stimulation significantly decreased total sleep time, compared to cathodal and sham stimulation. This effect was location specific. Bi-frontal cathodal stimulation did not significantly increase total sleep time, potentially due to ceiling effects in good sleepers. Exploratory resting-state EEG analyses prior to and after the tDCS protocols were consistent with the notion of increased cortical arousal after anodal stimulation and decreased cortical arousal after cathodal stimulation. The study provides proof-of-concept that total sleep time can be decreased by non-invasive bi-frontal anodal tDCS in healthy humans. Further elucidating the ‘top-down’ pathway of sleep-wake regulation is expected to increase knowledge on the fundamentals of sleep-wake regulation and to contribute to the development of novel treatments for clinical conditions of disturbed arousal and sleep.

Item Type: Article
Subjects : subj_Psychology
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
AuthorsEmailORCID
Frase, LUNSPECIFIEDUNSPECIFIED
Piosczyk, HUNSPECIFIEDUNSPECIFIED
Zittel, SUNSPECIFIEDUNSPECIFIED
Jahn, FUNSPECIFIEDUNSPECIFIED
Selhausen, PUNSPECIFIEDUNSPECIFIED
Krone, LUNSPECIFIEDUNSPECIFIED
Feige, BUNSPECIFIEDUNSPECIFIED
Mainberger, FUNSPECIFIEDUNSPECIFIED
Maier, JGUNSPECIFIEDUNSPECIFIED
Kuhn, MUNSPECIFIEDUNSPECIFIED
Kloppel, SUNSPECIFIEDUNSPECIFIED
Normann, CUNSPECIFIEDUNSPECIFIED
Sterr, AMUNSPECIFIEDUNSPECIFIED
Spiegelhalder, KUNSPECIFIEDUNSPECIFIED
Riemann, DUNSPECIFIEDUNSPECIFIED
Nitsche, MAUNSPECIFIEDUNSPECIFIED
Nissen, CUNSPECIFIEDUNSPECIFIED
Date : 1 June 2016
Identification Number : 10.1038/npp.2016.65
Copyright Disclaimer : Copyright 2016 Nature Publishing Group
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 12 Apr 2016 11:54
Last Modified : 01 Dec 2016 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/810412

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