Ultrasound Assisted Crystallization of Paracetamol: Crystal Size Distribution and Polymorph Control

Bhangu, SK, Ashokkumar, M and Lee, J (2016) Ultrasound Assisted Crystallization of Paracetamol: Crystal Size Distribution and Polymorph Control Crystal Growth and Design, 16. pp. 1934-1941.

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Abstract

Antisolvent crystallization of paracetamol was conducted using ultrasound. The effect of various ultrasonic frequencies and power on the mean crystal size, crystal size distribution, induction time, and type of polymorph obtained was studied. Multibubble sonoluminescence intensity was used to correlate the crystallization results with cavitation activity. Results showed that under optimum conditions ultrasound can significantly (i) reduce the mean crystal size from 170 to 13 μm, (ii) lower the induction time from 360 to 30 s, and (iii) narrow the size distribution. A close association between cavitation activity and rate of nucleation was observed. In addition, crystallization under sonication led to the formation of not only monoclinic polymorph (form I) but also orthorhombic polymorph (form II) of paracetamol, which is otherwise difficult to obtain in the absence of ultrasound

Item Type:	Article
Subjects :	Chemical and Process Engineering
Divisions :	Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :	Authors Email ORCID Bhangu, SK UNSPECIFIED UNSPECIFIED Ashokkumar, M UNSPECIFIED UNSPECIFIED Lee, J UNSPECIFIED UNSPECIFIED
Date :	9 March 2016
Identification Number :	https://doi.org/10.1021/acs.cgd.5b01470
Copyright Disclaimer :	Copyright © 2016 American Chemical Society
Depositing User :	Symplectic Elements
Date Deposited :	21 Apr 2016 11:08
Last Modified :	09 Mar 2017 02:08
URI:	http://epubs.surrey.ac.uk/id/eprint/810365

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