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Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients.

Manders, RJ, Hansen, D, Zorenc, AH, Dendale, P, Kloek, J, Saris, WH and van Loon, LJ (2014) Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients. J Med Food, 17 (7). pp. 758-763.

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Abstract

The capacity of nutritional protein to induce endogenous insulin secretion has been well established. However, it is not known whether such a response is applicable in a diverse population of type 2 diabetes patients. The aim of the present study was to assess the impact of co-ingesting either intact or hydrolyzed protein with carbohydrate on postprandial plasma insulin and glucose responses in type 2 diabetes patients. Sixty longstanding, male, type 2 diabetes patients participated in a study in which we determined postprandial plasma insulin and glucose responses after ingesting a single bolus of carbohydrate (0.7 g/kg: CHO) with or without an intact protein (0.3 g/kg: PRO) or its hydrolysate (0.3 g/kg: PROh). Results showed that protein co-ingestion strongly increased postprandial insulin release, with the insulin response +99 ± 41 and +110 ± 10% greater in the CHO+PRO and CHO+PROh experiments when compared with the CHO experiment. The insulinotropic properties of protein co-ingestion were evident in nearly all patients, with 58 out of 60 patients responding >10% when compared with the insulin response following carbohydrate ingestion only (CHO). The concomitant plasma glucose responses were 22 ± 32 and 23 ± 36% lower in the CHO+PRO and CHO+PROh experiments, respectively. We conclude that protein co-ingestion represents an effective dietary strategy to strongly augment postprandial insulin release and attenuate the postprandial rise in glucose concentration in type 2 diabetes patients.

Item Type: Article
Authors :
NameEmailORCID
Manders, RJUNSPECIFIEDUNSPECIFIED
Hansen, DUNSPECIFIEDUNSPECIFIED
Zorenc, AHUNSPECIFIEDUNSPECIFIED
Dendale, PUNSPECIFIEDUNSPECIFIED
Kloek, JUNSPECIFIEDUNSPECIFIED
Saris, WHUNSPECIFIEDUNSPECIFIED
van Loon, LJUNSPECIFIEDUNSPECIFIED
Date : July 2014
Identification Number : 10.1089/jmf.2012.0294
Uncontrolled Keywords : glucose, insulin, milk protein, protein hydrolysates, Adult, Aged, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Dietary Proteins, Double-Blind Method, Humans, Insulin, Male, Middle Aged, Postprandial Period, Protein Hydrolysates
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 10:59
Last Modified : 31 Oct 2017 18:10
URI: http://epubs.surrey.ac.uk/id/eprint/810332

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