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Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia.

Fornace, KM, Nuin, NA, Betson, M, Grigg, MJ, William, T, Anstey, NM, Yeo, TW, Cox, J, Ying, LT and Drakeley, CJ (2016) Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia. J Infect Dis, 213 (5). pp. 784-787.

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Abstract

Although asymptomatic carriage of human malaria species has been widely reported, the extent of asymptomatic, submicroscopic Plasmodium knowlesi parasitemia is unknown. In this study, samples were obtained from individuals residing in households or villages of symptomatic malaria cases with the aim of detecting submicroscopic P. knowlesi in this population. Four published molecular assays were used to confirm the presence of P. knowlesi. Latent class analysis revealed that the estimated proportion of asymptomatic individuals was 6.9% (95% confidence interval, 5.6%-8.4%). This study confirms the presence of a substantial number of asymptomatic monoinfections across all age groups; further work is needed to estimate prevalence in the wider community.

Item Type: Article
Subjects : Veterinary Parasitology
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Fornace, KMUNSPECIFIEDUNSPECIFIED
Nuin, NAUNSPECIFIEDUNSPECIFIED
Betson, MUNSPECIFIEDUNSPECIFIED
Grigg, MJUNSPECIFIEDUNSPECIFIED
William, TUNSPECIFIEDUNSPECIFIED
Anstey, NMUNSPECIFIEDUNSPECIFIED
Yeo, TWUNSPECIFIEDUNSPECIFIED
Cox, JUNSPECIFIEDUNSPECIFIED
Ying, LTUNSPECIFIEDUNSPECIFIED
Drakeley, CJUNSPECIFIEDUNSPECIFIED
Date : 1 March 2016
Identification Number : 10.1093/infdis/jiv475
Uncontrolled Keywords : Plasmodium knowlesi, asymptomatic parasitemia, malaria, submicroscopic infection
Related URLs :
Additional Information : © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/infdis/jiv475
Depositing User : Symplectic Elements
Date Deposited : 16 Mar 2016 09:35
Last Modified : 16 Mar 2016 09:35
URI: http://epubs.surrey.ac.uk/id/eprint/810233

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