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Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity

Jansen, CA, de Geus, E, van Haarlem, DA, van de Haar, PM, Loendt, BZ, Graham, SP, Goebel, TW, van Eden, W, Brookes, SM and Vervelde, L (2013) Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity SCIENTIFIC REPORTS, 3, ARTN 2478.

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Abstract

Infection of chickens with low pathogenicity avian influenza (LPAI) virus results in mild clinical signs while infection with highly pathogenic avian influenza (HPAI) viruses causes death of the birds within 36–48 hours. Since natural killer (NK) cells have been shown to play an important role in influenza-specific immunity, we hypothesise that NK cells are involved in this difference in pathogenicity. To investigate this, the role of chicken NK-cells in LPAI virus infection was studied. Next activation of lung NK cells upon HPAI virus infection was analysed. Infection with a H9N2 LPAI virus resulted in the presence of viral RNA in the lungs which coincided with enhanced activation of lung NK cells. The presence of H5N1 viruses, measured by detection of viral RNA, did not induce activation of lung NK cells. This suggests that decreased NK-cell activation may be one of the mechanisms associated with the enhanced pathogenicity of H5N1 viruses.

Item Type: Article
Subjects : Veterinary Science
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Jansen, CAUNSPECIFIEDUNSPECIFIED
de Geus, EUNSPECIFIEDUNSPECIFIED
van Haarlem, DAUNSPECIFIEDUNSPECIFIED
van de Haar, PMUNSPECIFIEDUNSPECIFIED
Loendt, BZUNSPECIFIEDUNSPECIFIED
Graham, SPUNSPECIFIEDUNSPECIFIED
Goebel, TWUNSPECIFIEDUNSPECIFIED
van Eden, WUNSPECIFIEDUNSPECIFIED
Brookes, SMUNSPECIFIEDUNSPECIFIED
Vervelde, LUNSPECIFIEDUNSPECIFIED
Date : 21 August 2013
Identification Number : 10.1038/srep02478
Copyright Disclaimer : This work is licensed under a Creative Commons Attribution 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, MULTIDISCIPLINARY SCIENCES, NATURAL-KILLER-CELLS, H5N1 VIRUS, A VIRUS, NKP46 DEFINES, T-CELLS, RECOGNITION, BIRDS, TRANSMISSION, SUBSETS, COMPLEX
Related URLs :
Additional Information : This work is licensed under a Creative Commons Attribution 3.0 Unported license. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0
Depositing User : Symplectic Elements
Date Deposited : 22 Mar 2016 15:27
Last Modified : 24 Mar 2016 09:27
URI: http://epubs.surrey.ac.uk/id/eprint/810178

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