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Purinergic signalling-evoked intracellular Ca(2+) concentration changes in the regulation of chondrogenesis and skeletal muscle formation.

Matta, C, Fodor, J, Csernoch, L and Zákány, R (2016) Purinergic signalling-evoked intracellular Ca(2+) concentration changes in the regulation of chondrogenesis and skeletal muscle formation. Cell Calcium.

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Abstract

It is now widely recognised that changes of the intracellular calcium concentration have deep impact on the differentiation of various non-excitable cells including the elements of the vertebrate skeleton. It has become evident that purinergic signalling is one of the most ancient cellular mechanisms that can cause such alterations in the intracellular Ca(2+)-homeostasis, which are precisely set either spatially or temporally. Purinergic signalling is believed to regulate intracellular Ca(2+)-concentration of developing cartilage and skeletal muscle cells and suggested to play roles in the modulation of various cellular functions. This idea is supported by the fact that pluripotent mesenchymal cells, chondroprogenitors or muscle precursors, as well as mature chondrocytes all are capable of releasing ectonucleotides, and express various types of purinoreceptors and ectonucleotidases. The presence of the basic components of purinergic signalling proves that cells of the chondrogenic lineage can utilise this mechanism for modulating their intracellular Ca(2+) concentration independently from the surrounding skeletal muscle and bone tissues, which are well known to release ectopurines during development and mechanical stress. In this review, we summarize accumulating experimental evidence supporting the importance of purinergic signalling in the regulation of chondrogenesis and during skeletal muscle formation.

Item Type: Article
Subjects : Biomedical Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Matta, CUNSPECIFIEDUNSPECIFIED
Fodor, JUNSPECIFIEDUNSPECIFIED
Csernoch, LUNSPECIFIEDUNSPECIFIED
Zákány, RUNSPECIFIEDUNSPECIFIED
Date : 16 February 2016
Identification Number : 10.1016/j.ceca.2016.01.006
Uncontrolled Keywords : ATP, Ca-oscillations, Cartilage formation, Mesenchymal stem cells, Myogenesis, Purinoreceptor
Related URLs :
Additional Information : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 16 Mar 2016 15:31
Last Modified : 16 Mar 2016 15:31
URI: http://epubs.surrey.ac.uk/id/eprint/810147

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