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Uveitis as a Result of MAP Kinase Pathway Inhibition.

Joshi, L, Karydis, A, Gemenetzi, M, Shao, EH and Taylor, SR (2013) Uveitis as a Result of MAP Kinase Pathway Inhibition. Case Rep Ophthalmol, 4 (3). pp. 279-282.

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Abstract

We report the case of a patient treated with dabrafenib and trametinib (mitogen-activated protein kinase pathway inhibitors) for stage 3b cutaneous melanoma who developed bilateral uveitis. Although there have been reports of ocular side effects with this class of drugs, uveitis has not been previously reported to the best of our knowledge. This case indicates the wide range of side effects that can be seen with the newer targeted biological therapies.

Item Type: Article
Subjects : Clinical Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Authors :
AuthorsEmailORCID
Joshi, LUNSPECIFIEDUNSPECIFIED
Karydis, AUNSPECIFIEDUNSPECIFIED
Gemenetzi, MUNSPECIFIEDUNSPECIFIED
Shao, EHUNSPECIFIEDUNSPECIFIED
Taylor, SRUNSPECIFIEDUNSPECIFIED
Date : September 2013
Identification Number : 10.1159/000357060
Uncontrolled Keywords : Dabrafenib, Melanoma, Trametinib, Uveitis
Related URLs :
Additional Information : This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0) (www.karger.com/OA-license-WT), applicable to the online version of the article only.
Depositing User : Symplectic Elements
Date Deposited : 11 Mar 2016 13:48
Last Modified : 11 Mar 2016 13:48
URI: http://epubs.surrey.ac.uk/id/eprint/810104

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