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Valacyclovir in the treatment of acute retinal necrosis

Taylor, SRJ, Hamilton, R, Hooper, CY, Joshi, L, Morarji, J, Gupta, N and Lightman, SL (2012) Valacyclovir in the treatment of acute retinal necrosis BMC OPHTHALMOLOGY, 12 (ARTN 4).

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Abstract

Background: To report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN). Methods: This study reports a retrospective, interventional case series of nine consecutive patients with ten eyes with newly diagnosed ARN treated with oral valacyclovir as the sole antiviral agent. Eight patients received oral valacyclovir 2 g tid (Valtrex, GlaxoSmithKline) and one patient with impaired renal function received oral 1 g tid. The main outcome measures were response to treatment, time to initial response to treatment, time to complete resolution of retinitis, best corrected visual acuity (BCVA) at final follow-up, retinal detachment and development of recurrent or second eye disease. Results: Retinitis resolved in ten of ten (100%) affected eyes. The median time to initial detectable response was seven days and the median time to complete resolution was 21 days. A final BCVA of 20/40 or better was achieved in 6/10 (60%) of eyes. 3/10 eyes (30%) developed a retinal detachment. No patients developed either disease reactivation or second eye involvement over the course of the study (mean follow up 31 weeks, range 7 to 104 weeks). Conclusions: Treatment with oral valacyclovir as the sole antiviral therapy resulted in complete resolution of retinitis. Final BCVA and retinal detachment rate were comparable with previously reported outcomes for intravenous acyclovir

Item Type: Article
Subjects : Clinical Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Clinical and Experimental Medicine
Authors :
AuthorsEmailORCID
Taylor, SRJUNSPECIFIEDUNSPECIFIED
Hamilton, RUNSPECIFIEDUNSPECIFIED
Hooper, CYUNSPECIFIEDUNSPECIFIED
Joshi, LUNSPECIFIEDUNSPECIFIED
Morarji, JUNSPECIFIEDUNSPECIFIED
Gupta, NUNSPECIFIEDUNSPECIFIED
Lightman, SLUNSPECIFIEDUNSPECIFIED
Date : 5 September 2012
Identification Number : 10.1186/1471-2415-12-48
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Ophthalmology, OPHTHALMOLOGY, Acute retinal necrosis, Herpetic retinitis, Acyclovir, Valacyclovir, PHARMACOKINETIC PROPERTIES, ANTIVIRAL ACTIVITY, INTRAVENOUS ACYCLOVIR, THERAPEUTIC-EFFICACY, ORAL VALACICLOVIR, OUTCOMES, FAMCICLOVIR, INFECTIONS, FEATURES, DISEASE
Related URLs :
Additional Information : © 2012 Taylor et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User : Symplectic Elements
Date Deposited : 11 Mar 2016 14:31
Last Modified : 11 Mar 2016 14:31
URI: http://epubs.surrey.ac.uk/id/eprint/810100

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