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Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group

Woodfield, R, UK Biobank Stroke Outcomes Group, and UK Biobank Follow-up and Outcomes Working Group, (2015) Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group PLoS One, 10 (9). pp. 1-14.

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Objective We performed a systematic review of the accuracy of patient self-report of stroke to inform approaches to ascertaining and confirming stroke cases in large prospective studies. Methods We sought studies comparing patient self-report against a reference standard for stroke. We extracted data on survey method(s), response rates, participant characteristics, the reference standard used, and the positive predictive value (PPV) of self-report. Where possible we also calculated sensitivity, specificity, negative predictive value (NPV), and stroke prevalence. Study-level risk of bias was assessed using the Quality Assessment of Diagnostic Studies tool (QUADAS-2). Results From >1500 identified articles, we included 17 studies. Most asked patients to report a lifetime history of stroke but a few limited recall time to 5 years. Some included questions for transient ischaemic attack (TIA) or stroke synonyms. No study was free of risk of bias in the QUADAS-2 assessment, the most frequent causes of bias being incomplete reference standard data, absence of blinding of adjudicators to self-report status, and participant response rates (<80%). PPV of self-report ranged from 22–87% (17 studies), sensitivity from 36–98% (10 studies), specificity from 96–99.6% (10 studies), and NPV from 88.2–99.9% (10 studies). PPV increased with stroke prevalence as expected. Among six studies with available relevant data, if confirmed TIAs were considered to be true rather than false positive strokes, PPV of self-report was >75% in all but one study. It was not possible to assess the influence of recall time or of the question(s) asked on PPV or sensitivity. Conclusions Characteristics of the study population strongly influence self-report accuracy. In population based studies with low stroke prevalence, a large proportion of self-reported strokes may be false positives. Self-report is therefore unlikely to be helpful for identifying cases without subsequent confirmation, but may be useful for case ascertainment in combination with other data sources.

Item Type: Article
Subjects : Health Care
Divisions : Faculty of Health and Medical Sciences
Authors :
UK Biobank Stroke Outcomes Group, UNSPECIFIEDUNSPECIFIED
UK Biobank Follow-up and Outcomes Working Group, UNSPECIFIEDUNSPECIFIED
Date : 10 September 2015
Identification Number : 10.1371/journal.pone.0137538
Additional Information : © 2015 Woodfield, Sudlow. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 03 Feb 2016 09:35
Last Modified : 03 Feb 2016 09:35

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