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Phenotypic and genetic relationships of bovine natural antibodies binding keyhole limpet hemocyanin in plasma and milk

de Klerk, B, Ducro, BJ, Heuven, HC, den Uyl, I, van Arendonk, JA, Parmentier, HK and van der Poel, JJ (2015) Phenotypic and genetic relationships of bovine natural antibodies binding keyhole limpet hemocyanin in plasma and milk Journal of Dairy Science.

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Abstract

To improve the health status (resilience) of dairy cows, levels of natural antibodies (NAb) might be useful. The objective of the present study was to compare levels and to estimate genetic parameters for NAb measured in milk and plasma samples. Titers of NAb IgM and IgG isotype-binding keyhole limpet hemocyanin of 2,919 cows, in both plasma and milk, were measured using ELISA. Analysis revealed that NAb levels in milk significantly increased with parity, whereas they remained constant in plasma. Moderate positive phenotypic correlations were found between NAb levels in milk and in plasma: 0.18 for IgG and 0.40 for IgM. This indicates that NAb from milk and plasma might reflect different aspects of dairy cow health status. However, high genetic correlations were found for NAb in milk and plasma: 0.81 for IgG and 0.79 for IgM. Heritabilities (SE in parentheses) for NAb measured in plasma [0.15 (0.05) for IgG and 0.25 (0.06) for IgM] were higher than heritabilities of NAb measured in milk [0.08 (0.03) for IgG and 0.23 (0.05) for IgM]. Our results indicate that NAb measured in milk and plasma are heritable and likely have a common genetic background, suggesting that NAb levels measured in milk might be useful for genetic improvement of disease resistance.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
de Klerk, BUNSPECIFIEDUNSPECIFIED
Ducro, BJUNSPECIFIEDUNSPECIFIED
Heuven, HCUNSPECIFIEDUNSPECIFIED
den Uyl, IUNSPECIFIEDUNSPECIFIED
van Arendonk, JAUNSPECIFIEDUNSPECIFIED
Parmentier, HKUNSPECIFIEDUNSPECIFIED
van der Poel, JJUNSPECIFIEDUNSPECIFIED
Date : 1 April 2015
Identification Number : 10.3168/jds
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 10:57
Last Modified : 28 Mar 2017 10:57
URI: http://epubs.surrey.ac.uk/id/eprint/809804

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