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A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutants.

Alejo, A, Saraiva, M, Ruiz-Argüello, MB, Viejo-Borbolla, A, de Marco, MF, Salguero, FJ and Alcami, A (2009) A method for the generation of ectromelia virus (ECTV) recombinants: in vivo analysis of ECTV vCD30 deletion mutants. PLoS One, 4 (4).

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Abstract

Ectromelia virus (ECTV) is the causative agent of mousepox, a lethal disease of mice with similarities to human smallpox. Mousepox progression involves replication at the initial site of infection, usually the skin, followed by a rapid spread to the secondary replicative organs, spleen and liver, and finally a dissemination to the skin, where the typical rash associated with this and other orthopoxviral induced diseases appears. Case fatality rate is genetically determined and reaches up to 100% in susceptible mice strains. Like other poxviruses, ECTV encodes a number of proteins with immunomodulatory potential, whose role in mousepox progression remains largely undescribed. Amongst these is a secreted homologue of the cellular tumour necrosis factor receptor superfamily member CD30 which has been proposed to modulate a Th1 immune response in vivo.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Alejo, AUNSPECIFIEDUNSPECIFIED
Saraiva, MUNSPECIFIEDUNSPECIFIED
Ruiz-Argüello, MBUNSPECIFIEDUNSPECIFIED
Viejo-Borbolla, AUNSPECIFIEDUNSPECIFIED
de Marco, MFUNSPECIFIEDUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Alcami, AUNSPECIFIEDUNSPECIFIED
Date : 13 April 2009
Identification Number : 10.1371/journal.pone.0005175
Uncontrolled Keywords : Animals, Antigens, CD30, Cell Line, Disease Progression, Ectromelia virus, Ectromelia, Infectious, Female, Humans, Ligands, Mice, Mice, Inbred BALB C, Mutation, Protein Multimerization, Recombination, Genetic, Viral Proteins, Virus Replication
Related URLs :
Additional Information : Copyright: � 2009 Alejo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 08 Jan 2016 12:50
Last Modified : 08 Jan 2016 12:50
URI: http://epubs.surrey.ac.uk/id/eprint/809662

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