Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity

Habiela, M, Seaga, J, Perez-Martin, E, Waters, R, Windsor, M, Salguero, FJ, Wood, J, Charleston, B and Juleff, N (2014) Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity JOURNAL OF GENERAL VIROLOGY, 95. pp. 2329-2345.

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Abstract

Laboratory animal models have provided valuable insight into foot-and-mouth disease virus (FMDV) pathogenesis in epidemiologically important target species. While not perfect, these models have delivered an accelerated time frame to characterize the immune responses in natural hosts and a platform to evaluate therapeutics and vaccine candidates at a reduced cost. Further expansion of these models in mice has allowed access to genetic mutations not available for target species, providing a powerful and versatile experimental system to interrogate the immune response to FMDV and to target more expensive studies in natural hosts. The purpose of this review is to describe commonly used FMDV infection models in laboratory animals and to cite examples of when these models have failed or successfully provided insight relevant for target species, with an emphasis on natural and vaccine-induced immunity.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :	Name Email ORCID Habiela, M Seaga, J Perez-Martin, E Waters, R Windsor, M Salguero, FJ Wood, J Charleston, B Juleff, N
Date :	1 November 2014
DOI :	10.1099/vir.0.068270-0
Uncontrolled Keywords :	Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Virology, INDEPENDENT ANTIBODY-RESPONSE, DELTA T-CELLS, VIRUS TYPE-O, GUINEA-PIGS, DENDRITIC CELLS, ESCAPE MUTANTS, MONOCLONAL-ANTIBODIES, INTERFERON INDUCERS, NONCODING REGIONS, PHARYNGEAL FLUID
Related URLs :	Author
Additional Information :	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/)
Depositing User :	Symplectic Elements
Date Deposited :	08 Jan 2016 11:58
Last Modified :	31 Oct 2017 17:58
URI:	http://epubs.surrey.ac.uk/id/eprint/809658

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