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The phytochemistry of a member of the meliaceae family and virtual screening for cytochrome P450 11 inhibitors.

Waratchareeyakul, Watcharee (2016) The phytochemistry of a member of the meliaceae family and virtual screening for cytochrome P450 11 inhibitors. Doctoral thesis, University of Surrey.

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Abstract

Eleven tetranortriterpenoids were isolated from the heartwood of X. rumphii and were identified as the limonoids, xylorumphiins L (RH.1), E (RH.2) and C (RH.3) and tetranortriterpenoids, xylorumphiins M-S (RH.4-10). Compounds RH.4-10 have a hemiacetal group which opens and closes in solution making it impossible to purify. Acetylation enabled separation of the R and S forms. Separation of the acetylated mixtures RH.4-10 led to the isolation of four acetylated derivatives of RH.4 (RH.4a-d), two acetylated derivatives of RH.5 (RH.5a and 5b), one acetylated derivative of RH.6 (RH.6a), two acetylated derivatives of RH.7 (RH.7a and 7b), one acetylated derivative of RH.8 (RH.8a) and one acetylated derivative of RH.10 (RH.10a). Compounds RH.1 and RH 4-10 have not been described previously.

Item Type: Thesis (Doctoral)
Divisions : Theses
Authors :
AuthorsEmailORCID
Waratchareeyakul, Watchareewatcharee.w@rbru.ac.thUNSPECIFIED
Date : 29 January 2016
Funders : The National Science and Technology Development Agency, Thailand
Contributors :
ContributionNameEmailORCID
Thesis supervisorMulholland, D.A.UNSPECIFIEDUNSPECIFIED
Depositing User : Watcharee Waratchareeyakul
Date Deposited : 09 Feb 2016 10:48
Last Modified : 09 Feb 2016 10:48
URI: http://epubs.surrey.ac.uk/id/eprint/809637

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