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Intracranial pressure for the characterization of different types of hydrocephalus: A Permutation Entropy study.

Adjei, T, Abásolo, D and Santamarta, D (2015) Intracranial pressure for the characterization of different types of hydrocephalus: A Permutation Entropy study. In: Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

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Abstract

Hydrocephalus is a condition characterized by altered cerebrospinal fluid (CSF) dynamics and chronic rises in intracranial pressure (ICP). However, the reason why hydrocephalic physiologies fail to inhibit dangerously high ICP levels is not known. Infusion studies are used to raise ICP and evaluate CSF circulation disorders. In this pilot study, ICP signals recorded during infusion tests from 33 patients with normal pressure hydrocephalus and 36 patients having developed a secondary form of normal pressure hydrocephalus were characterized using Permutation Entropy (PE), a symbolic non-linear method to quantify complexity. Each ICP signal was divided into four epochs - baseline (before infusion begins), infusion, plateau, and recovery (after infusion has stopped) - and the mean PE was calculated for each epoch. Statistically significant differences were found between PE for most epochs (p<;0.00833, Bonferroni-corrected Wilcoxon tests), with a significant decrease in the plateau phase. However, differences between PE for normal pressure and secondary hydrocephalus were not significant. Results suggest that the increase in ICP during infusion studies is associated with a significant decrease in PE. PE analysis of ICP signals could be useful for increasing our understanding of CSF dynamics in normal pressure hydrocephalus.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Engineering and Physical Sciences > Mechanical Engineering Sciences
Authors :
AuthorsEmailORCID
Adjei, TUNSPECIFIEDUNSPECIFIED
Abásolo, DUNSPECIFIEDUNSPECIFIED
Santamarta, DUNSPECIFIEDUNSPECIFIED
Date : 2015
Identification Number : 10.1109/EMBC.2015.7319320
Copyright Disclaimer : © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Contributors :
ContributionNameEmailORCID
PublisherIEEE, UNSPECIFIEDUNSPECIFIED
Related URLs :
Additional Information : © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Depositing User : Symplectic Elements
Date Deposited : 11 Feb 2016 09:45
Last Modified : 17 Feb 2016 09:26
URI: http://epubs.surrey.ac.uk/id/eprint/809631

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