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Aquaporin water channels in the mammary gland: from physiology to pathophysiology and neoplasia.

Mobasheri, A and Barrett-Jolley, R (2014) Aquaporin water channels in the mammary gland: from physiology to pathophysiology and neoplasia. J Mammary Gland Biol Neoplasia, 19 (1). pp. 91-102.

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Abstract

Aquaporins are membrane proteins that play fundamental roles in water and small solute transport across epithelial and endothelial barriers. Recent studies suggest that several aquaporin proteins are present in the mammary gland. Immunohistochemical techniques have confirmed the presence of aquaporin 1 (AQP1) and AQP3 water channels in rat, mouse, bovine and human mammary glands. Studies suggest that in addition to AQP1 and AQP3 AQP4, AQP5 and AQP7 proteins are expressed in different locations in the mammary gland. Aquaporins play key roles in tumor biology and are involved in cell growth, migration and formation of ascites via increased water permeability of micro-vessels. Emerging evidence suggests that expression of these proteins is altered in mammary tumors and in breast cancer cell lines although it is not yet clear whether this is a cause or a consequence of neoplastic development. This review analyzes the expression and potential functional roles of aquaporin water channels in the mammary gland. The physiological mechanisms involved in the transport of water and small solutes across mammary endothelial and epithelial barriers are discussed in the context of milk production and lactation. This paper also reviews papers from the recent cancer literature that implicate aquaporins in mammary neoplasia.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Date : March 2014
Identification Number : 10.1007/s10911-013-9312-6
Uncontrolled Keywords : Animals, Aquaporins, Female, Humans, Mammary Glands, Animal, Mammary Glands, Human, Neoplasms, Water
Related URLs :
Additional Information : Copyright The Author(s) 2013. This article is published with open access at Springerlink.com
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 11:08
Last Modified : 23 Dec 2015 11:08
URI: http://epubs.surrey.ac.uk/id/eprint/809559

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