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The future of osteoarthritis therapeutics: emerging biological therapy.

Mobasheri, A (2013) The future of osteoarthritis therapeutics: emerging biological therapy. Curr Rheumatol Rep, 15 (12).

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Abstract

Biological therapy is a thriving area of research and development, and is well established for chronic forms of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, there is no clinically validated biological therapy for osteoarthritis (OA). Chronic forms of OA are increasingly viewed as an inflammatory disease. OA was largely regarded as a "wear and tear disease". However, the disease is now believed to involve "low grade" inflammation and the growth of blood vessels and nerves from the subchondral bone into articular cartilage. This realization has focused research effort on the development and evaluation of biological therapy that targets proinflammatory mediators, angiogenic factors and cytokines in articular cartilage, subchondral bone and synovium in chronic forms of OA. This review article provides an overview of emerging biological therapy for OA, and discusses recent molecular targets implicated in angiogenesis and neurogenesis and progress with antibody-based therapy, calcitonin, and kartogenin, the small molecule stimulator of chondrogenesis.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : December 2013
Identification Number : 10.1007/s11926-013-0385-4
Uncontrolled Keywords : Angiogenesis Inhibitors, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Biological Therapy, Calcitonin, Humans, Inflammation Mediators, Neurogenesis, Osteoarthritis, Osteoarthritis, Knee
Related URLs :
Additional Information : Copyright The Author(s) 2013. This article is published with open access at Springerlink.com
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 11:16
Last Modified : 23 Dec 2015 11:16
URI: http://epubs.surrey.ac.uk/id/eprint/809555

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