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Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

Mobasheri, A, Henrotin, Y, Biesalski, HK and Shakibaei, M (2012) Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci, 13 (4). pp. 4202-4232.

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Abstract

Interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surface receptors and activate inflammatory signaling pathways culminating with the activation of nuclear factor κB (NF-κB), a transcription factor that can be triggered by a host of stress-related stimuli including, excessive mechanical stress and ECM degradation products. Once activated, NF-κB regulates the expression of many cytokines, chemokines, adhesion molecules, inflammatory mediators, and several matrix-degrading enzymes. Therefore, proinflammatory cytokines, their cell surface receptors, NF-κB and downstream signaling pathways are therapeutic targets in OA. This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Henrotin, YUNSPECIFIEDUNSPECIFIED
Biesalski, HKUNSPECIFIEDUNSPECIFIED
Shakibaei, MUNSPECIFIEDUNSPECIFIED
Date : 30 March 2012
Identification Number : 10.3390/ijms13044202
Uncontrolled Keywords : OA, RA, articular cartilage, curcumin, functional food, osteoarthritis, phytochemical, resveratrol, rheumatoid arthritis, Angiogenesis Inhibitors, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Rheumatoid, Cartilage, Articular, Chondrocytes, Curcumin, Humans, Inflammation, Interleukin-1beta, Joints, Osteoarthritis, Phytochemicals, Phytotherapy, Stilbenes, Transcription Factor RelA, Tumor Necrosis Factor-alpha
Related URLs :
Additional Information : © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 12:47
Last Modified : 23 Dec 2015 12:47
URI: http://epubs.surrey.ac.uk/id/eprint/809550

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