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Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

Musumeci, G, Castrogiovanni, P, Trovato, FM, Weinberg, AM, Al-Wasiyah, MK, Alqahtani, MH and Mobasheri, A (2015) Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16 (9). pp. 20560-20575.

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Abstract

© 2015 by the authors; licensee MDPI, Basel, Switzerland. Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facilitate the development of novel therapies that may eliminate the cause or, at least, slow down the degenerative processes in OA. The aim of this review was to explore the molecular markers and signals that induce chondrocyte apoptosis in OA. A literature search was conducted in PubMed, Scopus, Web of Science and Google Scholar using the keywords chondrocyte death, apoptosis, osteoarthritis, autophagy and biomarker. Several molecules considered to be markers of chondrocyte apoptosis will be discussed in this brief review. Molecular markers and signalling pathways associated with chondroycte apoptosis may turn out to be therapeutic targets in OA and approaches aimed at neutralizing apoptosis-inducing molecules may at least delay the progression of cartilage degeneration in OA.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Musumeci, GUNSPECIFIEDUNSPECIFIED
Castrogiovanni, PUNSPECIFIEDUNSPECIFIED
Trovato, FMUNSPECIFIEDUNSPECIFIED
Weinberg, AMUNSPECIFIEDUNSPECIFIED
Al-Wasiyah, MKUNSPECIFIEDUNSPECIFIED
Alqahtani, MHUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : 1 September 2015
Identification Number : 10.3390/ijms160920560
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, Chemistry, osteoarthritis (OA), chondrocyte death, apoptosis, autophagy, biomarker, HUMAN ARTICULAR CHONDROCYTES, NECROSIS-FACTOR-ALPHA, TEMPOROMANDIBULAR-JOINT DISC, MESENCHYMAL STEM-CELLS, TOLL-LIKE RECEPTORS, IN-VITRO MODEL, NITRIC-OXIDE, CARTILAGE DEGENERATION, MECHANICAL COMPRESSION, RHEUMATOID-ARTHRITIS
Related URLs :
Additional Information : © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 09:53
Last Modified : 23 Dec 2015 09:53
URI: http://epubs.surrey.ac.uk/id/eprint/809544

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