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Increased and Mistimed Sex Hormone Production in Night Shift Workers

Papantoniou, K, Pozo, OJ, Espinosa, A, Marcos, J, Castano-Vinyals, G, Basagana, X, Juanola Pages, E, Mirabent, J, Martin, J, Such Faro, P, Gasco Aparici, A, Middleton, B, Skene, DJ and Kogevinas, M (2015) Increased and Mistimed Sex Hormone Production in Night Shift Workers CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 24 (5). pp. 854-863.

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Abstract

BACKGROUND: Night shift work has been associated with an increased risk for breast and prostate cancer. The effect of circadian disruption on sex steroid production is a possible underlying mechanism, underinvestigated in humans. We have assessed daily rhythms of sex hormones and melatonin in night and day shift workers of both sexes. METHODS: We recruited 75 night and 42 day workers, ages 22 to 64 years, in different working settings. Participants collected urine samples from all voids over 24 hours on a working day. Urinary concentrations of 16 sex steroid hormones and metabolites (estrogens, progestagens, and androgens) and 6-sulfatoxymelatonin were measured in all samples. Mean levels and peak time of total and individual metabolite production were compared between night and day workers. RESULTS: Night workers had higher levels of total progestagens [geometric mean ratio (GMR) 1.65; 95% confidence intervals (CI), 1.17-2.32] and androgens (GMR: 1.44; 95% CI, 1.03-2.00), compared with day workers, after adjusting for potential confounders. The increased sex hormone levels among night shift workers were not related to the observed suppression of 6-sulfatoxymelatonin. Peak time of androgens was significantly later among night workers, compared with day workers (testosterone: 12:14 hours; 10:06-14:48 vs. 08:35 hours; 06:52-10:46). CONCLUSIONS: We found increased levels of progestagens and androgens as well as delayed peak androgen production in night shift workers compared with day workers. IMPACT: The increase and mistiming of sex hormone production may explain part of the increased risk for hormone-related cancers observed in night shift workers.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Papantoniou, KUNSPECIFIEDUNSPECIFIED
Pozo, OJUNSPECIFIEDUNSPECIFIED
Espinosa, AUNSPECIFIEDUNSPECIFIED
Marcos, JUNSPECIFIEDUNSPECIFIED
Castano-Vinyals, GUNSPECIFIEDUNSPECIFIED
Basagana, XUNSPECIFIEDUNSPECIFIED
Juanola Pages, EUNSPECIFIEDUNSPECIFIED
Mirabent, JUNSPECIFIEDUNSPECIFIED
Martin, JUNSPECIFIEDUNSPECIFIED
Such Faro, PUNSPECIFIEDUNSPECIFIED
Gasco Aparici, AUNSPECIFIEDUNSPECIFIED
Middleton, BUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Kogevinas, MUNSPECIFIEDUNSPECIFIED
Date : 1 May 2015
Identification Number : 10.1158/1055-9965.EPI-14-1271
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Oncology, Public, Environmental & Occupational Health, BREAST-CANCER RISK, MODULATES AROMATASE-ACTIVITY, PREMENOPAUSAL WOMEN, LIGHT EXPOSURE, URINARY 6-SULFATOXYMELATONIN, CIRCADIAN DISRUPTION, POSTMENOPAUSAL WOMEN, ENDOGENOUS ESTROGEN, MELATONIN TREATMENT, PROSTATE-CANCER
Related URLs :
Additional Information : ©2015 American Association for Cancer Research.
Depositing User : Symplectic Elements
Date Deposited : 09 Dec 2015 09:53
Last Modified : 01 May 2016 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/809448

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