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Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia.

Manders, RJ, Little, JP, Forbes, SC and Candow, DG (2012) Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia. NUTRIENTS, 4 (11). pp. 1664-1678.

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Abstract

The loss of muscle mass and strength with aging (i.e., sarcopenia) has a negative effect on functional independence and overall quality of life. One main contributing factor to sarcopenia is the reduced ability to increase skeletal muscle protein synthesis in response to habitual feeding, possibly due to a reduction in postprandial insulin release and an increase in insulin resistance. Branched-chain amino acids (BCAA), primarily leucine, increases the activation of pathways involved in muscle protein synthesis through insulin-dependent and independent mechanisms, which may help counteract the "anabolic resistance" to feeding in older adults. Leucine exhibits strong insulinotropic characteristics, which may increase amino acid availability for muscle protein synthesis, reduce muscle protein breakdown, and enhance glucose disposal to help maintain blood glucose homeostasis.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Manders, RJUNSPECIFIEDUNSPECIFIED
Little, JPUNSPECIFIEDUNSPECIFIED
Forbes, SCUNSPECIFIEDUNSPECIFIED
Candow, DGUNSPECIFIEDUNSPECIFIED
Date : 8 November 2012
Identification Number : 10.3390/nu4111664
Uncontrolled Keywords : Aging, Amino Acids, Branched-Chain, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Leucine, Muscle Proteins, Muscle, Skeletal, Sarcopenia
Related URLs :
Additional Information : © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 14:40
Last Modified : 23 Dec 2015 14:40
URI: http://epubs.surrey.ac.uk/id/eprint/809353

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