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Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients

Hansen, D, Dendale, P, Jonkers, RAM, Beelen, M, Manders, RJF, Corluy, L, Mullens, A, Berger, J, Meeusen, R and van Loon, LJC (2009) Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients DIABETOLOGIA, 52 (9). pp. 1789-1797.

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Abstract

Aims/hypothesis: Exercise represents an effective interventional strategy to improve glycaemic control in type 2 diabetes patients. However, the impact of exercise intensity on the benefits of exercise training remains to be established. In the present study, we compared the clinical benefits of 6 months of continuous low- to moderate-intensity exercise training with those of continuous moderate- to high-intensity exercise training, matched for energy expenditure, in obese type 2 diabetes patients. Methods: Fifty male obese type 2 diabetes patients (age 59∈±∈8 years, BMI 32∈± ∈4 kg/m2) participated in a 6 month continuous endurance-type exercise training programme. All participants performed three supervised exercise sessions per week, either 55 min at 50% of whole body peak oxygen uptake left(VO2peak) (low to moderate intensity) or 40 min at 75% of VO2peak (moderate to high intensity). Oral glucose tolerance, blood glycated haemoglobin, lipid profile, body composition, maximal workload capacity, whole body and skeletal muscle oxidative capacity and skeletal muscle fibre type composition were assessed before and after 2 and 6 months of intervention. Results: The entire 6 month intervention programme was completed by 37 participants. Continuous endurance-type exercise training reduced blood glycated haemoglobin levels, LDL-cholesterol concentrations, body weight and leg fat mass, and increased VO2peak, lean muscle mass and skeletal muscle cytochrome c oxidase and citrate synthase activity (p∈<∈0. 05). No differences were observed between the groups training at low to moderate or moderate to high intensity. Conclusions/interpretation: When matched for energy cost, prolonged continuous low- to moderate-intensity endurance-type exercise training is equally effective as continuous moderate- to high-intensity training in lowering blood glycated haemoglobin and increasing whole body and skeletal muscle oxidative capacity in obese type 2 diabetes patients. © 2009 Springer-Verlag.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Hansen, DUNSPECIFIEDUNSPECIFIED
Dendale, PUNSPECIFIEDUNSPECIFIED
Jonkers, RAMUNSPECIFIEDUNSPECIFIED
Beelen, MUNSPECIFIEDUNSPECIFIED
Manders, RJFUNSPECIFIEDUNSPECIFIED
Corluy, LUNSPECIFIEDUNSPECIFIED
Mullens, AUNSPECIFIEDUNSPECIFIED
Berger, JUNSPECIFIEDUNSPECIFIED
Meeusen, RUNSPECIFIEDUNSPECIFIED
van Loon, LJCUNSPECIFIEDUNSPECIFIED
Date : 1 September 2009
Identification Number : 10.1007/s00125-009-1354-3
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, ENDOCRINOLOGY & METABOLISM, Diabetes, Glycaemic control, Lifestyle intervention, Training modalities, POSTPRANDIAL GLUCOSE-HOMEOSTASIS, CORONARY-ARTERY-DISEASE, HUMAN SKELETAL-MUSCLE, INSULIN-RESISTANCE, GLYCEMIC CONTROL, MITOCHONDRIAL DYSFUNCTION, NIDDM PATIENTS, INDIVIDUALS, METABOLISM, INCREASES
Related URLs :
Additional Information : Copyright The Author(s) 2009. This article is published with open access at Springerlink.com
Depositing User : Symplectic Elements
Date Deposited : 23 Dec 2015 14:37
Last Modified : 23 Dec 2015 14:37
URI: http://epubs.surrey.ac.uk/id/eprint/809352

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