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Effectiveness of trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results

de Lusignan, S, Pebody, R, Warburton, F, Andrews, N, Ellis, J, von Wissman, B, Robertson, C, Yonova, I, Cottrell, S, Gallagher, N, Green, H, Thompson, C, Galiano, M, Marques, D, Gunson, R, Reynolds, A, Moore, C, Mullett, D, Pathirannehelage, S, Donati, M, Johnston, J, McMenamin, J and Zambon, M (2015) Effectiveness of trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results Eurosurveillance, 20 (36), 15-003. pp. 1-18.

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Abstract

The 2014/15 influenza season in the United Kingdom (UK) was characterised by circulation of predominantly antigenically and genetically drifted influenza A(H3N2) and B viruses. A universal paediatric influenza vaccination programme using a quadrivalent live attenuated influenza vaccine (LAIV) has recently been introduced in the UK. This study aims to measure the end-of-season influenza vaccine effectiveness (VE), including for LAIV, using the test negative case–control design. The overall adjusted VE against all influenza was 34.3% (95% confidence interval (CI) 17.8 to 47.5); for A(H3N2) 29.3% (95% CI: 8.6 to 45.3) and for B 46.3% (95% CI: 13.9 to 66.5). For those aged under 18 years, influenza A(H3N2) LAIV VE was 35% (95% CI: −29.9 to 67.5), whereas for influenza B the LAIV VE was 100% (95% CI:17.0 to 100.0). Although the VE against influenza A(H3N2) infection was low, there was still evidence of significant protection, together with moderate, significant protection against drifted circulating influenza B viruses. LAIV provided non-significant positive protection against influenza A, with significant protection against B. Further work to assess the population impact of the vaccine programme across the UK is underway.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
de Lusignan, SUNSPECIFIEDUNSPECIFIED
Pebody, RUNSPECIFIEDUNSPECIFIED
Warburton, FUNSPECIFIEDUNSPECIFIED
Andrews, NUNSPECIFIEDUNSPECIFIED
Ellis, JUNSPECIFIEDUNSPECIFIED
von Wissman, BUNSPECIFIEDUNSPECIFIED
Robertson, CUNSPECIFIEDUNSPECIFIED
Yonova, IUNSPECIFIEDUNSPECIFIED
Cottrell, SUNSPECIFIEDUNSPECIFIED
Gallagher, NUNSPECIFIEDUNSPECIFIED
Green, HUNSPECIFIEDUNSPECIFIED
Thompson, CUNSPECIFIEDUNSPECIFIED
Galiano, MUNSPECIFIEDUNSPECIFIED
Marques, DUNSPECIFIEDUNSPECIFIED
Gunson, RUNSPECIFIEDUNSPECIFIED
Reynolds, AUNSPECIFIEDUNSPECIFIED
Moore, CUNSPECIFIEDUNSPECIFIED
Mullett, DUNSPECIFIEDUNSPECIFIED
Pathirannehelage, SUNSPECIFIEDUNSPECIFIED
Donati, MUNSPECIFIEDUNSPECIFIED
Johnston, JUNSPECIFIEDUNSPECIFIED
McMenamin, JUNSPECIFIEDUNSPECIFIED
Zambon, MUNSPECIFIEDUNSPECIFIED
Date : 10 September 2015
Identification Number : 10.2807/1560-7917.ES.2015.20.36.30013
Additional Information : Copyright 2015 European Centre for Disease Prevention and Control
Depositing User : Symplectic Elements
Date Deposited : 11 Nov 2015 15:52
Last Modified : 11 Nov 2015 15:52
URI: http://epubs.surrey.ac.uk/id/eprint/809258

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