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Effectiveness of trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results

de Lusignan, S, Pebody, R, Warburton, F, Andrews, N, Ellis, J, von Wissman, B, Robertson, C, Yonova, I, Cottrell, S, Gallagher, N , Green, H, Thompson, C, Galiano, M, Marques, D, Gunson, R, Reynolds, A, Moore, C, Mullett, D, Pathirannehelage, S, Donati, M, Johnston, J, McMenamin, J and Zambon, M (2015) Effectiveness of trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 end of season results Eurosurveillance, 20 (36), 15-003. pp. 1-18.

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Abstract

The 2014/15 influenza season in the United Kingdom (UK) was characterised by circulation of predominantly antigenically and genetically drifted influenza A(H3N2) and B viruses. A universal paediatric influenza vaccination programme using a quadrivalent live attenuated influenza vaccine (LAIV) has recently been introduced in the UK. This study aims to measure the end-of-season influenza vaccine effectiveness (VE), including for LAIV, using the test negative case–control design. The overall adjusted VE against all influenza was 34.3% (95% confidence interval (CI) 17.8 to 47.5); for A(H3N2) 29.3% (95% CI: 8.6 to 45.3) and for B 46.3% (95% CI: 13.9 to 66.5). For those aged under 18 years, influenza A(H3N2) LAIV VE was 35% (95% CI: −29.9 to 67.5), whereas for influenza B the LAIV VE was 100% (95% CI:17.0 to 100.0). Although the VE against influenza A(H3N2) infection was low, there was still evidence of significant protection, together with moderate, significant protection against drifted circulating influenza B viruses. LAIV provided non-significant positive protection against influenza A, with significant protection against B. Further work to assess the population impact of the vaccine programme across the UK is underway.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Authors :
NameEmailORCID
de Lusignan, S
Pebody, R
Warburton, F
Andrews, N
Ellis, J
von Wissman, B
Robertson, C
Yonova, I
Cottrell, S
Gallagher, N
Green, H
Thompson, C
Galiano, M
Marques, D
Gunson, R
Reynolds, A
Moore, C
Mullett, D
Pathirannehelage, S
Donati, M
Johnston, J
McMenamin, J
Zambon, M
Date : 10 September 2015
Identification Number : 10.2807/1560-7917.ES.2015.20.36.30013
Additional Information : Copyright 2015 European Centre for Disease Prevention and Control
Depositing User : Symplectic Elements
Date Deposited : 11 Nov 2015 15:52
Last Modified : 11 Nov 2015 15:52
URI: http://epubs.surrey.ac.uk/id/eprint/809258

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