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Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs

Iadevaia, V and Gerber, AP (2015) Combinatorial Control of mRNA Fates by RNA-Binding Proteins and Non-Coding RNAs Biomolecules, 5 (4). pp. 2207-2222.

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Abstract

Post-transcriptional control of gene expression is mediated by RNA-binding proteins (RBPs) and small non-coding RNAs (e.g., microRNAs) that bind to distinct elements in their mRNA targets. Here, we review recent examples describing the synergistic and/or antagonistic effects mediated by RBPs and miRNAs to determine the localisation, stability and translation of mRNAs in mammalian cells. From these studies, it is becoming increasingly apparent that dynamic rearrangements of RNA-protein complexes could have profound implications in human cancer, in synaptic plasticity, and in cellular differentiation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :
AuthorsEmailORCID
Iadevaia, VUNSPECIFIEDUNSPECIFIED
Gerber, APUNSPECIFIEDUNSPECIFIED
Date : 24 September 2015
Identification Number : 10.3390/biom5042207
Uncontrolled Keywords : gene expression, post-transcriptional control, RNA-binding protein, microRNA, ribonucleoprotein complex, combinatorial control
Additional Information : © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Depositing User : Symplectic Elements
Date Deposited : 30 Oct 2015 18:34
Last Modified : 30 Oct 2015 18:34
URI: http://epubs.surrey.ac.uk/id/eprint/809132

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