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Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation

Giskeodegard, GF, Davies, SK, Revell, VL, Keun, H and Skene, DJ (2015) Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation SCIENTIFIC REPORTS, 5, ARTN 1.

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Abstract

Understanding how metabolite levels change over the 24 hour day is of crucial importance for clinical and epidemiological studies. Additionally, the association between sleep deprivation and metabolic disorders such as diabetes and obesity requires investigation into the links between sleep and metabolism. Here, we characterise time-of-day variation and the effects of sleep deprivation on urinary metabolite profiles. Healthy male participants (n = 15) completed an in-laboratory study comprising one 24 h sleep/wake cycle prior to 24 h of continual wakefulness under highly controlled environmental conditions. Urine samples were collected over set 2-8 h intervals and analysed by (1)H NMR spectroscopy. Significant changes were observed with respect to both time of day and sleep deprivation. Of 32 identified metabolites, 7 (22%) exhibited cosine rhythmicity over at least one 24 h period; 5 exhibiting a cosine rhythm on both days. Eight metabolites significantly increased during sleep deprivation compared with sleep (taurine, formate, citrate, 3-indoxyl sulfate, carnitine, 3-hydroxyisobutyrate, TMAO and acetate) and 8 significantly decreased (dimethylamine, 4-DTA, creatinine, ascorbate, 2-hydroxyisobutyrate, allantoin, 4-DEA, 4-hydroxyphenylacetate). These data indicate that sampling time, the presence or absence of sleep and the response to sleep deprivation are highly relevant when identifying biomarkers in urinary metabolic profiling studies.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Giskeodegard, GFUNSPECIFIEDUNSPECIFIED
Davies, SKUNSPECIFIEDUNSPECIFIED
Revell, VLUNSPECIFIEDUNSPECIFIED
Keun, HUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Date : 9 October 2015
Identification Number : 10.1038/srep14843
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, P-CRESYL SULFATE, INDOXYL SULFATE, SPECTROSCOPY, IDENTIFICATION, TAURINE, DEPRESSION, PREGNANCY, PROFILES, PLASMA, OXIDE
Related URLs :
Additional Information : This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Depositing User : Symplectic Elements
Date Deposited : 11 Nov 2015 10:13
Last Modified : 11 Nov 2015 10:14
URI: http://epubs.surrey.ac.uk/id/eprint/809128

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