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Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae

Hill, SC, Murphy, AA, Cotten, M, Palser, AL, Benson, P, Lesellier, S, Gormley, E, Richomme, C, Grierson, S, Bhuachalla, DN, Chambers, M, Kellam, P, Boschiroli, M-L, Ehlers, B, Jarvis, MA and Pybus, OG (2015) Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae Journal of General Virology, 96 (6). pp. 1411-1422.

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Abstract

Polyomaviruses infect a diverse range of mammalian and avian hosts, and are associated with a variety of symptoms. However, it is unknown whether the viruses are found in all mammalian families and the evolutionary history of the polyomaviruses is still unclear. Here, we report the discovery of a novel polyomavirus in the European badger (Meles meles), which to our knowledge represents the first polyomavirus to be characterized in the family Mustelidae, and within a European carnivoran. Although the virus was discovered serendipitously in the supernatant of a cell culture inoculated with badger material, we subsequently confirmed its presence in wild badgers. The European badger polyomavirus was tentatively named Meles meles polyomavirus 1 (MmelPyV1). The genome is 5187 bp long and encodes proteins typical of polyomaviruses. Phylogenetic analyses including all known polyomavirus genomes consistently group MmelPyV1 with California sea lion polyomavirus 1 across all regions of the genome. Further evolutionary analyses revealed phylogenetic discordance amongst polyomavirus genome regions, possibly arising from evolutionary rate heterogeneity, and a complex association between polyomavirus phylogeny and host taxonomic groups.

Item Type: Article
Authors :
AuthorsEmailORCID
Hill, SCUNSPECIFIEDUNSPECIFIED
Murphy, AAUNSPECIFIEDUNSPECIFIED
Cotten, MUNSPECIFIEDUNSPECIFIED
Palser, ALUNSPECIFIEDUNSPECIFIED
Benson, PUNSPECIFIEDUNSPECIFIED
Lesellier, SUNSPECIFIEDUNSPECIFIED
Gormley, EUNSPECIFIEDUNSPECIFIED
Richomme, CUNSPECIFIEDUNSPECIFIED
Grierson, SUNSPECIFIEDUNSPECIFIED
Bhuachalla, DNUNSPECIFIEDUNSPECIFIED
Chambers, MUNSPECIFIEDUNSPECIFIED
Kellam, PUNSPECIFIEDUNSPECIFIED
Boschiroli, M-LUNSPECIFIEDUNSPECIFIED
Ehlers, BUNSPECIFIEDUNSPECIFIED
Jarvis, MAUNSPECIFIEDUNSPECIFIED
Pybus, OGUNSPECIFIEDUNSPECIFIED
Date : 1 June 2015
Identification Number : 10.1099/vir.0.000071
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Virology, MOLECULAR-BIOLOGY, GENOME ANALYSIS, DNA VIRUSES, T-ANTIGENS, BATS, HERPESVIRUS-1, PHYLOGENY, EMERGENCE
Related URLs :
Additional Information : This is an open access article published by the Microbiology Society under the Creative Commons Attribution License
Depositing User : Symplectic Elements
Date Deposited : 11 Nov 2015 15:56
Last Modified : 11 Nov 2015 15:56
URI: http://epubs.surrey.ac.uk/id/eprint/809036

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