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Effect of Subcutaneous Insulin Detemir on Glucose Flux, Lipolysis and Electroencephalography in Type 1 Diabetes.

Herring, R, Knight, R, Shojaee-Moradie, F, Johnsen, S, Umpleby, AM, Jackson, N, Jones, R, Dijk, DJ and Russell-Jones, DL (2015) Effect of Subcutaneous Insulin Detemir on Glucose Flux, Lipolysis and Electroencephalography in Type 1 Diabetes. Diabetes Obes Metab.

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Abstract

To investigate the effects of subcutaneous detemir on glucose flux, lipid metabolism and brain function, twelve people with type 1 diabetes received in random order 0.5Units/kgBW detemir or NPH insulin. Glucose concentration was clamped at 5mmol/L then increased to 10mmol/L. Glucose production rate (glucose Ra), glucose uptake (glucose Rd) and glycerol production (glycerol Ra) were measured with a constant iv infusion of [6,6(2) H2 ]glucose and [(2) H5 ]glycerol. Electroencephalography direct (DC) and alternating (AC) current potentials were measured. While detemir induced comparable effects on glucose Ra, glucose Rd and glycerol Ra during euglycaemia, compared with NPH, it triggered a distinct negative shift in DC-potentials, with significant treatment effect in frontal cerebrocortical channels (p<0.001). AC spectral power showed significant differences in theta and alpha frequencies during euglycaemia (p=0.03). Subcutaneous detemir exerts different effects on brain function when compared with NPH in people with type 1 diabetes.This may be an important mechanism behind the limitation of weight gain with detemir.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Herring, RUNSPECIFIEDUNSPECIFIED
Knight, RUNSPECIFIEDUNSPECIFIED
Shojaee-Moradie, FUNSPECIFIEDUNSPECIFIED
Johnsen, SUNSPECIFIEDUNSPECIFIED
Umpleby, AMUNSPECIFIEDUNSPECIFIED
Jackson, NUNSPECIFIEDUNSPECIFIED
Jones, RUNSPECIFIEDUNSPECIFIED
Dijk, DJUNSPECIFIEDUNSPECIFIED
Russell-Jones, DLUNSPECIFIEDUNSPECIFIED
Date : 29 September 2015
Identification Number : 10.1111/dom.12553
Uncontrolled Keywords : Insulin detemir, glucose metabolism, lipid metabolism, type 1 diabetes, weight
Related URLs :
Additional Information : This is the peer reviewed version of the following article: Herring R, Knight R, Shojaee-Moradie F, Johnsen S, Umpleby AM, Jackson N, Jones R, Dijk DJ, Russell-Jones DL, (2015) Effect of Subcutaneous Insulin Detemir on Glucose Flux, Lipolysis and Electroencephalography in Type 1 Diabetes, which has been published in final form at http://dx.doi.org/10.1111/dom.12553. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Depositing User : Symplectic Elements
Date Deposited : 13 Oct 2015 18:04
Last Modified : 29 Sep 2016 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/808808

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