University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Sleep restores behavioral plasticity to drosophila mutants

Dissel, S, Angadi, V, Kirszenblat, L, Suzuki, Y, Donlea, J, Klose, M, Koch, Z, English, D, Winsky-Sommerer, R, Van Swinderen, B and Shaw, PJ (2015) Sleep restores behavioral plasticity to drosophila mutants Current Biology, 25 (10). pp. 1270-1281.

[img]
Preview
Text
Dissel et al_Current Biology2015.pdf
Available under License : See the attached licence file.

Download (1MB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Given the role that sleep plays in modulating plasticity, we hypothesized that increasing sleep would restore memory to canonical memory mutants without specifically rescuing the causal molecular lesion. Sleep was increased using three independent strategies: activating the dorsal fan-shaped body, increasing the expression of Fatty acid binding protein (dFabp), or by administering the GABA-A agonist 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP). Short-term memory (STM) or long-term memory (LTM) was evaluated in rutabaga (rut) and dunce (dnc) mutants using aversive phototaxic suppression and courtship conditioning. Each of the three independent strategies increased sleep and restored memory to rut and dnc mutants. Importantly, inducing sleep also reverses memory defects in a Drosophila model of Alzheimer's disease. Together, these data demonstrate that sleep plays a more fundamental role in modulating behavioral plasticity than previously appreciated and suggest that increasing sleep may benefit patients with certain neurological disorders.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
AuthorsEmailORCID
Dissel, SUNSPECIFIEDUNSPECIFIED
Angadi, VUNSPECIFIEDUNSPECIFIED
Kirszenblat, LUNSPECIFIEDUNSPECIFIED
Suzuki, YUNSPECIFIEDUNSPECIFIED
Donlea, JUNSPECIFIEDUNSPECIFIED
Klose, MUNSPECIFIEDUNSPECIFIED
Koch, ZUNSPECIFIEDUNSPECIFIED
English, DUNSPECIFIEDUNSPECIFIED
Winsky-Sommerer, RUNSPECIFIEDUNSPECIFIED
Van Swinderen, BUNSPECIFIEDUNSPECIFIED
Shaw, PJUNSPECIFIEDUNSPECIFIED
Date : 1 January 2015
Identification Number : 10.1016/j.cub.2015.03.027
Additional Information : © 2015 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 13:55
Last Modified : 18 May 2016 01:08
URI: http://epubs.surrey.ac.uk/id/eprint/808745

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800