Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration

Zanos, P, Georgiou, P, Metaxas, A, Kitchen, I, Winsky-Sommerer, R and Bailey, A (2015) Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration NEUROSCIENCE LETTERS, 600. pp. 33-37.

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Abstract

Nicotine addiction is considered to be the main preventable cause of death worldwide. While growing evidence indicates that the neurohypophysial peptide oxytocin can modulate the addictive properties of several abused drugs, the regulation of the oxytocinergic system following nicotine administration has so far received little attention. Here, we examined the effects of long-term nicotine or saline administration on the central oxytocinergic system using [(125)I]OVTA autoradiographic binding in mouse brain. Male, 7-week old C57BL6J mice were treated with either nicotine (7.8 mg/kg daily; rate of 0.5 μl per hour) or saline for a period of 14-days via osmotic minipumps. Chronic nicotine administration induced a marked region-specific upregulation of the oxytocin receptor binding in the amygdala, a brain region involved in stress and emotional regulation. These results provide direct evidence for nicotine-induced neuroadaptations in the oxytocinergic system, which may be involved in the modulation of nicotine-seeking as well as emotional consequence of chronic drug use.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :	Name Email ORCID Zanos, P Georgiou, P Metaxas, A Kitchen, I Winsky-Sommerer, R Bailey, A
Date :	23 July 2015
DOI :	10.1016/j.neulet.2015.05.054
Uncontrolled Keywords :	Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Nicotine, Oxytocin receptor, Amygdala, Mice, DRUG-ADDICTION, RATS, AMYGDALA, DEPRESSION, DEPENDENCE, SMOKING, FEAR, HYPOTHALAMUS, VASOPRESSIN, TOLERANCE
Related URLs :	Author
Additional Information :	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User :	Symplectic Elements
Date Deposited :	07 Oct 2015 13:30
Last Modified :	23 Jul 2016 01:08
URI:	http://epubs.surrey.ac.uk/id/eprint/808743

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