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The emerging chondrocyte channelome

Barrett-Jolley, R, Lewis, R, Fallman, R and Mobasheri, A (2010) The emerging chondrocyte channelome FRONTIERS IN PHYSIOLOGY, 1, UNSP 1.

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Abstract

Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a range of mechanical and biochemical stimuli. These responses are necessary for the maintenance of viable cartilage and may be compromised in inflammatory diseases such as arthritis. Although chondrocytes are non-excitable cells their plasma membrane contains a rich complement of ion channels. This diverse channelome appears to be as complex as one might expect to find in excitable cells although, in the case of chondrocytes, their functions are far less well understood. The ion channels so far identified in chondrocytes include potassium channels (K(ATP), BK, K(v), and SK), sodium channels (epithelial sodium channels, voltage activated sodium channels), transient receptor potential calcium or non-selective cation channels and chloride channels. In this review we describe this emerging channelome and discuss the possible functions of a range of chondrocyte ion channels.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Lewis, RUNSPECIFIEDUNSPECIFIED
Fallman, RUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : 1 January 2010
Identification Number : 10.3389/fphys.2010.00135
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Physiology, chondrocyte, K-v channel, K-ATP channel, BK (MaxiK) channel, ENaC
Related URLs :
Additional Information : Copyright © 2010 Barrett-Jolley, Lewis, Fallman and Mobasheri. This is an openaccess article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 17:43
Last Modified : 07 Oct 2015 17:43
URI: http://epubs.surrey.ac.uk/id/eprint/808690

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