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A proteomics study of the response of North Ronaldsay sheep to copper challenge.

Simpson, DM, Mobasheri, A, Haywood, S and Beynon, RJ (2006) A proteomics study of the response of North Ronaldsay sheep to copper challenge. BMC Vet Res, 2.

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Abstract

BACKGROUND: The objective of this proteomics study was to identify proteins that changed expression as a result of copper challenge in the uniquely copper sensitive North Ronaldsay sheep and further, to compare those changes in expression with the more copper tolerant Cambridge breed. Such data gives us a proteome-centered perspective of the pathogenesis of copper-induced oxidative stress in this breed. RESULTS: Many proteins respond to copper challenge, but this study focuses on those exhibiting a differential response between the two breeds, related to liver copper content. As copper accumulated in the tissue, the pattern of expression of several proteins was markedly different, in North Ronaldsay sheep as compared to the Cambridge breed. CONCLUSION: The pattern of changes was consistent with the greatly enhanced susceptibility of North Ronaldsay sheep to copper-induced oxidative stress, focused on mitochondrial disturbance with consequent activation of hepatic stellate cells. The expression profiles were sufficiently complex that the response could not simply be explained as a hypersensitivity to copper in North Ronaldsay sheep.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Simpson, DMUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Haywood, SUNSPECIFIEDUNSPECIFIED
Beynon, RJUNSPECIFIEDUNSPECIFIED
Date : 27 December 2006
Identification Number : 10.1186/1746-6148-2-36
Uncontrolled Keywords : Animals, Copper, Dose-Response Relationship, Drug, Female, Gene Expression Profiling, Gene Expression Regulation, Liver, Oligonucleotide Array Sequence Analysis, Oxidative Stress, Proteomics, Sheep
Related URLs :
Additional Information : © 2006 Simpson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 18:00
Last Modified : 07 Oct 2015 18:00
URI: http://epubs.surrey.ac.uk/id/eprint/808684

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