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High hopes for cannabinoid agonists in the treatment of rheumatic diseases

Staunton, CA, Mobasheri, A and Barrett-Jolley, R (2014) High hopes for cannabinoid agonists in the treatment of rheumatic diseases BMC MUSCULOSKELETAL DISORDERS, 15, ARTN 4.

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Abstract

There are two well-characterised isoforms of cannabinoid receptor; CB1 and CB2 and of these CB2 is under active investigation as a potential target for treatment of the chronic pain associated with widespread and intractable joint diseases osteoarthritis and rheumatoid arthritis. The recent report by Fukuda et al (BMC Musculoskelet Disord 15:275, 2014) in BMC Musculoskeletal Disorders investigates the efficacy of a selective CB2 agonist, JW133, in both in vitro and in vivo models of rheumatoid arthritis and provides encouraging data. The report shows that JW133 inhibits expression of the CCL2 cytokine, osteoclastogenesis and reduces histological indicators of joint degeneration. Each of these could potentially contribute to beneficial analgesic effects in a therapeutic context.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Staunton, CAUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Date : 4 December 2014
Identification Number : 10.1186/1471-2474-15-410
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Orthopedics, Rheumatology, Cannabinoids, Cannabis, Chronic pain, Dorsal root ganglia, Ion channels, Fibroblast-like synoviocytes (FLS), JW133, Osteoarthritis (OA), Rheumatoid Arthritis (RA), POTENTIAL THERAPEUTIC TARGET, FIBROBLAST-LIKE SYNOVIOCYTES, SYNOVIAL FIBROBLASTS, GLOBAL BURDEN, OSTEOARTHRITIS, RECEPTOR, ARTHRITIS, PATHOGENESIS, CB2, PERSPECTIVE
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Additional Information : © 2014 Staunton et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 09:14
Last Modified : 07 Oct 2015 09:14
URI: http://epubs.surrey.ac.uk/id/eprint/808682

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