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The crossroads between cancer stem cells and aging

Franco, SS, Raveh-Amit, H, Kobolak, J, Alqahtani, MH, Mobasheri, A and Dinnyes, A (2015) The crossroads between cancer stem cells and aging BMC CANCER, 15 (Supp 1), ARTN S.

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Abstract

The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existence of CSCs came from advances in the field of haematological malignancies. Thus far, putative CSCs have been isolated from various solid and non-solid tumours and shown to possess self-renewal, differentiation, and cancer regeneration properties. Although research in the field is progressing extremely fast, proof of concept for the CSC hypothesis is still lacking and key questions remain unanswered, e.g. the cell of origin for these cells. Nevertheless, it is undisputed that neoplastic transformation is associated with genetic and epigenetic alterations of normal cells, and a better understanding of these complex processes is of utmost importance for developing new anti-cancer therapies. In the present review, we discuss the CSC hypothesis with special emphasis on age-associated alterations that govern carcinogenesis, at least in some types of tumours. We present evidence from the scientific literature for age-related genetic and epigenetic alterations leading to cancer and discuss the main challenges in the field.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Franco, SSUNSPECIFIEDUNSPECIFIED
Raveh-Amit, HUNSPECIFIEDUNSPECIFIED
Kobolak, JUNSPECIFIEDUNSPECIFIED
Alqahtani, MHUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Dinnyes, AUNSPECIFIEDUNSPECIFIED
Date : 15 January 2015
Identification Number : 10.1186/1471-2407-15-S1-S1
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Oncology, TUMOR-INITIATING CELLS, ACUTE MYELOID-LEUKEMIA, TEMPLATE DNA STRANDS, HEAT-SHOCK FACTOR-1, BREAST-CANCER, SELF-RENEWAL, PROGENITOR CELLS, HUMAN-DISEASE, IN-VITRO, NEOPLASTIC TRANSFORMATION
Related URLs :
Additional Information : © 2015 Franco et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 09:09
Last Modified : 07 Oct 2015 09:09
URI: http://epubs.surrey.ac.uk/id/eprint/808681

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