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Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

Musumeci, G, Aiello, FC, Szychlinska, MA, Di Rosa, M, Castrogiovanni, P and Mobasheri, A (2015) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16 (3). pp. 6093-6112.

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Abstract

Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. In the past, OA was considered a wear and tear disease, leading to the loss of articular cartilage and joint disability. Nowadays, thanks to advancements in molecular biology, OA is believed to be a very complex multifactorial disease. OA is a degenerative disease characterized by "low-grade inflammation" in cartilage and synovium, resulting in the loss of joint structure and progressive deterioration of cartilage. Although the disease can be dependent on genetic and epigenetic factors, sex, ethnicity, and age (cellular senescence, apoptosis and lubricin), it is also associated with obesity and overweight, dietary factors, sedentary lifestyle and sport injuries. The aim of this review is to highlight how certain behaviors, habits and lifestyles may be involved in the onset and progression of OA and to summarize the principal risk factors involved in the development of this complicated joint disorder

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Musumeci, GUNSPECIFIEDUNSPECIFIED
Aiello, FCUNSPECIFIEDUNSPECIFIED
Szychlinska, MAUNSPECIFIEDUNSPECIFIED
Di Rosa, MUNSPECIFIEDUNSPECIFIED
Castrogiovanni, PUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : 1 March 2015
Identification Number : 10.3390/ijms16036093
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, Chemistry, HUMAN ARTICULAR CHONDROCYTES, GLYCATION END-PRODUCTS, INTERSTITIAL FLUID PRESSURIZATION, MATRIX-METALLOPROTEINASE 13, MESENCHYMAL STEM-CELLS, 1ST NATIONAL-HEALTH, IN-VITRO MODEL, KNEE OSTEOARTHRITIS, METABOLIC SYNDROME, LUBRICIN EXPRESSION
Related URLs :
Additional Information : © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 09:03
Last Modified : 07 Oct 2015 09:03
URI: http://epubs.surrey.ac.uk/id/eprint/808680

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