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Physicochemical and biomechanical stimuli in cell-based articular cartilage repair.

Jahr, H, Matta, C and Mobasheri, A (2015) Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. Curr Rheumatol Rep, 17 (3).

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Abstract

Articular cartilage is a unique load-bearing connective tissue with a low intrinsic capacity for repair and regeneration. Its avascularity makes it relatively hypoxic and its unique extracellular matrix is enriched with cations, which increases the interstitial fluid osmolarity. Several physicochemical and biomechanical stimuli are reported to influence chondrocyte metabolism and may be utilized for regenerative medical approaches. In this review article, we summarize the most relevant stimuli and describe how ion channels may contribute to cartilage homeostasis, with special emphasis on intracellular signaling pathways. We specifically focus on the role of calcium signaling as an essential mechanotransduction component and highlight the role of phosphatase signaling in this context.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Jahr, HUNSPECIFIEDUNSPECIFIED
Matta, CUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : March 2015
Identification Number : 10.1007/s11926-014-0493-9
Related URLs :
Additional Information : Copyright The Author(s) 2015. This article is published with open access at Springerlink.com
Depositing User : Symplectic Elements
Date Deposited : 07 Oct 2015 09:06
Last Modified : 07 Oct 2015 09:06
URI: http://epubs.surrey.ac.uk/id/eprint/808678

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